Results 51 to 60 of about 27,769 (271)

Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells

Cell Reports, 2023
Summary: While dysbiosis in the gut is implicated in the impaired induction of oral tolerance generated in mesenteric lymph nodes (MesLNs), how dysbiosis affects this process remains unclear.
Tomohiro Fukaya, Tomofumi Uto, Shuya Mitoma, Hideaki Takagi, Yotaro Nishikawa, Moe Tominaga, Narantsog Choijookhuu, Yoshitaka Hishikawa, Katsuaki Sato   +8 more
doaj   +1 more source

Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. [PDF]

PLoS ONE, 2014
Dendritic cells (DCs) can be sub-divided into various subsets that play specialized roles in priming of adaptive immune responses. Atherosclerosis is regarded as a chronic inflammatory disease of the vessel wall and DCs can be found in non-inflamed and ...
Martin Busch, Thilo C Westhofen, Miriam Koch, Manfred B Lutz, Alma Zernecke   +4 more
doaj   +1 more source

Spatial Distribution and Densities of CD103+ and FoxP3+ Tumor Infiltrating Lymphocytes by Digital Analysis for Outcome Prediction in Breast Cancer

The Oncologist, 2023
Background The evaluation of tumor-infiltrating lymphocytes (TILs) for breast cancer prognosis is now established. However, the clinical value for their spatial distributions of specific immune subsets, namely CD103+ tissue-resident memory T cells FoxP3+
R. Chan, C. Aphivatanasiri, I. Poon, J. Tsang, Yun-Bi Ni, M. Lacambra, J. Li, Conrad H. C. Lee, G. Tse   +8 more
semanticscholar   +1 more source

CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion

Frontiers in Immunology, 2018
Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance.
Steve Swain, Mandi M. Roe, Thomas A. Sebrell, Barkan Sidar, Jennifer Dankoff, Rachel VanAusdol, Lesley E. Smythies, Phillip D. Smith, Diane Bimczok   +8 more
doaj   +1 more source

Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. [PDF]

PLoS ONE, 2013
Steady state dendritic cells (DC) found in non-lymphoid tissue sites under normal physiologic conditions play a pivotal role in triggering T cell responses upon immune provocation. CD11b+ and CD103+ DC have received considerable attention in this regard.
Payal Khandelwal, Tomas Blanco-Mezquita, Parisa Emami, Hyun Soo Lee, Nancy J Reyes, Rose Mathew, Randy Huang, Daniel R Saban   +7 more
doaj   +1 more source

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Immunity, 2020
Summary Dendritic cells (DCs) are antigen-presenting cells controlling T cell activation. In humans, the diversity, ontogeny, and functional capabilities of DC subsets are not fully understood. Here, we identified circulating CD88−CD1c+CD163+ DCs (called
Pierre Bourdely, Giorgio Anselmi, K. Vaivode, R. Ramos, Y. Missolo-Koussou, Sofía Hidalgo, Jimena Tosselo, N. Núñez, W. Richer, A. Vincent-Salomon, A. Saxena, Kristie Wood, Á. Lladser, E. Piaggio, J. Helft, P. Guermonprez   +15 more
semanticscholar   +1 more source

CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling

Nature Communications
Immune mechanisms contribute to the neuropathology of Alzheimer’s disease (AD) but the role of adaptive immune cells is unclear. Here we show that the brain CD8+ T cell compartment is dysregulated in AD patients and in the 3xTg-AD mouse model ...
Eleonora Terrabuio, E. Pietronigro, A. Bani, V. della Bianca, C. Laudanna, Barbara Rossi, Giulia Finotti, Bruno Santos-Lima, Elena Zenaro, Ermanna Turano, Gabriele Tosadori, M. Calgaro, Nicola Vitulo, Monica Castellucci, Daniela Cecconi, Jessica Brandi, Nikolaos Vareltzakis, Fabiana Mainieri, Antonella Calore, G. Angelini, Bruno Bonetti, Gabriela Constantin   +21 more
semanticscholar   +1 more source

NLRP6 deficiency expands a novel CD103+ B cell population that confers immune tolerance in NOD mice

Frontiers in Immunology, 2023
Introduction Gut microbiota have been linked to modulating susceptibility to Type 1 diabetes; however, there are many ways in which the microbiota interact with host cells, including through microbial ligand binding to intracellular inflammasomes (large ...
J. Pearson, Jian Peng, Juan Huang, Xiao-Qing Yu, N. Tai, You-Jia Hu, Sha Sha, R. Flavell, Hongyu Zhao, F. Wong, L. Wen   +10 more
semanticscholar   +1 more source

Involvement of αEβ7 (CD103) in the pathogenesis of autoimmune diseases

Japanese Journal of Clinical Immunology, 2014
αEβ7 (CD103), one of integrin family molecules, is a heterodimer consisting of an αE subunit and a β7 subunit. αEβ7 is expressed in several subsets of lymphocytes including T cells, intestinal intraepithelial lymphocytes and lamina propria lymphocytes.
YOSHIMOTO, Keiko, KURASAWA, Takahiko, SUZUKI, Katsuya, TAKEUCHI, Tsutomu   +3 more
openaire   +3 more sources

CD103⁺ Cells and Chemokine Receptor Expression in Breast Cancer

Immune Network, 2023
Mucosal environments harbour lymphocytes, which express several adhesion molecules, including intestinal homing receptors and integrin αE/β7 (CD103). CD103 binds E-cadherin, an integrin receptor expressed in intestinal endothelial cells. Its expression not only enables homing or retention of T lymphocytes at these sites but is also associated with ...
Eun-Hye Seo, Ga-Yun Song, Chung-Sik Oh, Seong-Hyop Kim, Wan-Seop Kim, Seung-Hyun Lee   +5 more
openaire   +2 more sources