Results 111 to 120 of about 27,769 (271)

Association of CD103+ T cell infiltration with overall survival in solid tumors of the digestive tract and its potential in anti-PD-1 treatment: A review and meta-analysis

Biomedical Papers, 2022
We looked into the most recent studies of digestive tumor patients and performed a meta-analysis to explore the association of CD103+ T cell infiltration with overall survival (OS) in solid tumors of the digestive duct. Major databases were searched. The
Wei Wei, Yun Ding, Jiajia He, Jun Wu
doaj   +1 more source

Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition

Immunity, 2016
Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant BRAF or fail to respond to checkpoint blockade. We explored whether modulation of intratumoral antigen presenting cells (APCs) could increase responses to these ...
Hélène Salmon, J. Idoyaga, A. Rahman, M. Leboeuf, R. Remark, Stefan Jordan, M. Casanova-Acebes, Makhzuna N. Khudoynazarova, J. Agudo, Navpreet Tung, S. Chakarov, Christina Rivera, Brandon Hogstad, M. Bosenberg, D. Hashimoto, S. Gnjatic, N. Bhardwaj, A. Palucka, Brian D. Brown, J. Brody, F. Ginhoux, M. Merad   +21 more
semanticscholar   +1 more source

The Role of IL-2Rβ-dependent Signaling and CD103 in Regulatory T Cells for Mucosal Tolerance

, 2016
A network of mechanisms operates to maintain tolerance in the gut mucosa. CD103 marks many lymphoid cells, including regulatory T cells (Tregs), within the gut. CD103+ Tregs represent a subset of Tregs with potent suppressor function in vitro and in vivo.
Yuan, Xiaomei
core   +2 more sources

Migratory CD103+CD11b+ cDC2 cells in Peyer's patches are critical for gut IgA responses following oral immunization.

Mucosal Immunology
Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP).
I. Gribonika, Anneli Strömberg, Rakesh K. Chandode, Karin Schön, K. Lahl, M. Bemark, N. Lycke   +6 more
semanticscholar   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

CD103− and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells [PDF]

The Journal of Immunology, 2007
Abstract Dendritic cells (DC) are able to capture, process, and present exogenous Ag to CD8+ T lymphocytes through MHC class I, a process referred to as cross-presentation. In this study, we demonstrate that CD103+ (CD11chighCD11blow) and CD103− (CD11cintCD11bhigh) DC residing in the lung-draining bronchial lymph node (brLN) have ...
Maria-Luisa, del Rio, Jose-Ignacio, Rodriguez-Barbosa, Elisabeth, Kremmer, Reinhold, Förster   +3 more
openaire   +2 more sources

Supplementary figures legend from Paxillin Binding to the Cytoplasmic Domain of CD103 Promotes Cell Adhesion and Effector Functions for CD8⁺ Resident Memory T Cells in Tumors

, 2017
S. Figure 1. Involvement of Pxn in CD103-mediated adhesion and spreading of CD8+/CD103+ TRM cells. S. Figure 2. T-cell treatment with saracatinib or infection with shRNA targeting Pxn does not alter cell viability and cell surface protein expression ...
Fathia Mami-Chouaib (10499830), Gwendoline Gros (14922206), Pierre Validire (228310), Ludiane Gauthier (14922203), Marie Boutet (14914043), Stéphanie Corgnac (14913261), Georges Bismuth (246382)   +6 more
core   +1 more source

Quantitative and qualitative deficits in neonatal lung-migratory dendritic cells impact the generation of the CD8+ T cell response. [PDF]

PLoS Pathogens, 2014
CD103+ and CD11b+ populations of CD11c+MHCIIhi murine dendritic cells (DCs) have been shown to carry antigens from the lung through the afferent lymphatics to mediastinal lymph nodes (MLN).
Tracy J Ruckwardt, Allison M W Malloy, Kaitlyn M Morabito, Barney S Graham   +3 more
doaj   +1 more source

Retinoic acid‐loaded liposomes induce human mucosal CD103+ dendritic cells that inhibit Th17 cells and drive regulatory T‐cell development in vitro

European Journal of Immunology
The active vitamin A metabolite, all‐trans‐retinoic acid (RA), primes precursor dendritic cells (DCs) into a mucosal phenotype with tolerogenic properties characterized by the expression of integrin CD103.
N. Nagy, F. Hafkamp, R. Sparrius, R. Bas, Fernando Lozano Vigario, T. V. van Capel, R. van Ree, T. Geijtenbeek, B. Slütter, S. Tas, Esther C. de Jong   +10 more
semanticscholar   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source