Results 51 to 60 of about 4,753,527 (236)

Activation of NF-κB signaling in tissue-resident memory T cells promotes recurrent psoriasis in mice

Frontiers in Immunology
BackgroundRecurrence triggered by immunological memory is a critical challenge in the treatment of psoriasis. Tissue-resident memory T (Trm) cells are the primary pacemakers in recurrent psoriasiform dermatitis following stimulation and infection by ...
Yukang Lin, Jiaying Chen, Han Du, Yuchao Chen, Zhaolin Liu, Xuejia Li, Yongdan Li, Feifei Qiu, Lingling Wen, Siyuan Xu, Siyuan Xu, Huazhen Liu   +11 more
doaj   +1 more source

Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program

JCI Insight, 2021
Tissue-resident memory T cells (TRM) provide frontline defense against infectious diseases and contribute to antitumor immunity; however, aside from the necessity of TGF-β, knowledge regarding TRM-inductive cues remains incomplete, particularly for human
Farah Hasan, Yulun Chiu, Rebecca M. Shaw, Junmei Wang, Cassian Yee   +4 more
doaj   +1 more source

Table_2_HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.xlsx

, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Alex K. Shalek (1291083), Osaretin E. Asowata (11777852), Warren Kuhn (5740346), Bonnie Berger (19458), Philip Goulder (87977), Søren Buus (49944), J. Zachary Porterfield (6904217), Thumbi Ndung’u (159362), Jennifer Giandhari (9543786), Alasdair Leslie (735478), Samita Singh (13974384), Rishan Bipath (13974390), Frank Anderson (4055212), Son Nguyen (525816), Alveera Singh (9442604), Abigail Ngoepe (5740340), Farina Karim (2577766), Andile L. Sibiya (13974387), Dirhona Ramjit (8858981), Kumeshan Moodley (13974393), Ntombifuthi Mthabela (13974381), Sarah K. Nyquist (13777944), Rabiah Fardoos (4678399), Tulio de Oliveira (68362), Henrik N. Kløverpris (9440270), Samuel W. Kazer (1870930)   +25 more
core   +1 more source

Deep immune phenotyping and single-cell transcriptomics allow identification of circulating TRM-like cells which correlate with liver-stage immunity and vaccine-induced protection from malaria [PDF]

, 2022
Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination, involves sequential viral-vectored vaccination by intramuscular and ...
Jonathan Sheridan, Mohammad Ali Husainy, Amy Flaxman, Andrés Noé, Naveen Prasad, Alexandra J. Spencer, Daniel Jenkin, Duncan Bellamy, Fernando Ramos Lopez, Adrian V. S. Hill, Rebecca A. Makinson, Katie J. Ewer, Mehreen S. Datoo, Richard Morter, Dimitrios Voukantsis   +14 more
core   +1 more source

Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery

OncoImmunology
Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome in solid cancer patients.
Syrine Abdeljaoued, Alexandre Doussot, Marie Kroemer, Emilien Laloy, Jean René Pallandre, Antoine El Kaddissi, Laurie Spehner, Myriam Ben Khelil, Adeline Bouard, Virginie Mougey, Ugo Chartral, Angélique Vienot, Julien Viot, Zaher Lakkis, Franck Monnien, Romain Loyon, Christophe Borg   +16 more
doaj   +1 more source

The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection

Viruses, 2021
Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major focus was on CD8+ TRM, there has recently been increased interest in defining the phenotype and the role of CD4+ TRM in diseases.
Thomas R. O’Neil, Kevin Hu, Naomi R. Truong, Sana Arshad, Barbara L. Shacklett, Anthony L. Cunningham, Najla Nasr   +6 more
doaj   +1 more source

Table_8_HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.xlsx

, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Alex K. Shalek (1291083), Osaretin E. Asowata (11777852), Warren Kuhn (5740346), Bonnie Berger (19458), Philip Goulder (87977), Søren Buus (49944), J. Zachary Porterfield (6904217), Thumbi Ndung’u (159362), Jennifer Giandhari (9543786), Alasdair Leslie (735478), Samita Singh (13974384), Rishan Bipath (13974390), Frank Anderson (4055212), Son Nguyen (525816), Alveera Singh (9442604), Abigail Ngoepe (5740340), Farina Karim (2577766), Andile L. Sibiya (13974387), Dirhona Ramjit (8858981), Kumeshan Moodley (13974393), Ntombifuthi Mthabela (13974381), Sarah K. Nyquist (13777944), Rabiah Fardoos (4678399), Tulio de Oliveira (68362), Henrik N. Kløverpris (9440270), Samuel W. Kazer (1870930)   +25 more
core   +1 more source

Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity

Frontiers in Immunology, 2018
Resident memory (TRM) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal TRM ...
Aleksey Molodtsov, Mary Jo Turk
doaj   +1 more source

TGF-β induced transcriptional profiles are enriched for the TRM-related signature genes identified in murine TRM cells.

, 2019
(A-C) The bar plots show the log2 fold change in expression (x-axes) of the 35 TRM-related signature genes in each of the pairwise comparison of the TGF-β-treated groups vs. TGF-β-untreated groups.
Artika P. Nath (390048), Thomas Gebhardt (615361), Michael Inouye (103694), Francis R. Carbone (567638), Asolina Braun (3064941), Scott C. Ritchie (6320948), Laura K. Mackay (255723)   +6 more
core   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source