Results 61 to 70 of about 4,753,527 (236)

CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer

Cell Communication and Signaling
Background Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate of patient mortality. CD8+ tissue-resident memory T (TRM) cells are strategically positioned
Zi-Xin Wu, Tian-Tian Da, Chuan Huang, Xiao-Qing Wang, Liang Li, Zhi-Bin Zhao, Ting-Ting Yin, Hai-Qing Ma, Zhe-Xiong Lian, Jie Long, Fei Wang, Jie Cao   +11 more
doaj   +1 more source

Niches for the Long-Term Maintenance of Tissue-Resident Memory T Cells

Frontiers in Immunology, 2018
Tissue-resident memory T cells (TRM cells) are a population of immune cells that reside in the lymphoid and non-lymphoid organs without recirculation through the blood.
Shiki Takamura
doaj   +1 more source

CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types

Nature Communications, 2023
Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory
Leandro Barros, Daryna Piontkivska, Patrícia Figueiredo-Campos, Júlia Fanczal, Sofia Pereira Ribeiro, Marta Baptista, Silvia Ariotti, Nuno Santos, Maria João Amorim, Cristina Silva Pereira, Marc Veldhoen, Cristina Ferreira   +11 more
doaj   +1 more source

Table_4_HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control.xlsx

, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Alex K. Shalek (1291083), Osaretin E. Asowata (11777852), Warren Kuhn (5740346), Bonnie Berger (19458), Philip Goulder (87977), Søren Buus (49944), J. Zachary Porterfield (6904217), Thumbi Ndung’u (159362), Jennifer Giandhari (9543786), Alasdair Leslie (735478), Samita Singh (13974384), Rishan Bipath (13974390), Frank Anderson (4055212), Son Nguyen (525816), Alveera Singh (9442604), Abigail Ngoepe (5740340), Farina Karim (2577766), Andile L. Sibiya (13974387), Dirhona Ramjit (8858981), Kumeshan Moodley (13974393), Ntombifuthi Mthabela (13974381), Sarah K. Nyquist (13777944), Rabiah Fardoos (4678399), Tulio de Oliveira (68362), Henrik N. Kløverpris (9440270), Samuel W. Kazer (1870930)   +25 more
core   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Heterogeneity and plasticity of tissue-resident memory T cells in skin diseases and homeostasis: a review

Frontiers in Immunology
Skin tissue-resident memory T (Trm) cells are produced by antigenic stimulation and remain in the skin for a long time without entering the peripheral circulation.
Guomu Liu, Ziyue Wang, Shanshan Li
doaj   +1 more source

memory T cells in the epidermis [PDF]

, 2023
Tissue-resident memory CD8+ T cells (TRM) reside at sites of previous infection, providing protection against reinfection with the same pathogen. In the skin, TRM patrol the epidermis, where keratinocytes are the entry site for many viral infections ...
Katrin Hodapp, Sabine Muth, Radsak, Markus P., Markus P. Radsak, Björn E. Clausen, Clausen, Björn E., Gregory Harms, Probst, Hans Christian, Felix Melchior, Raker, Verena K., Hans Christian Probst, Bartneck, Joschka, Brand, Anna, Nadine Kamenjarin, Melchior, Felix, Hodapp, Katrin, Ann-Kathrin Hartmann, Christian Becker, Joschka Bartneck, Hansjörg Schild, Muth, Sabine, Verena K. Raker, Anna Brand, Schild, Hansjörg, Harms, Gregory, Becker, Christian, Kamenjarin, Nadine, Hartmann, Ann-Kathrin   +27 more
core   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists

Gut and Liver
Liver tissue-resident memory T (TRM) cells play a pivotal role in hepatic immune responses. Their unique residence within liver sinusoids allow continuous antigen surveillance.
Ji Won Han, Eui-Cheol Shin
doaj   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source