Results 41 to 50 of about 70,024 (278)
Cancer immunology research, 2022 The host microbiota is tightly associated with tumor initiation and progression in multiple solid tumors including gastric cancer (GC). The aim of this study was to investigate in patients with GC whether there are alterations in gastric microbiota and ...
R. Peng +9 more
semanticscholar +1 more source
Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin
Cell Reports, 2019 Summary: Tissue-resident memory (TRM) CD8+ T cells are positioned within environmental barrier tissues to provide a first line of defense against pathogen entry, but whether these specialized T cell populations can be readily boosted to increase ...
Samuel J. Hobbs, Jeffrey C. Nolz
doaj +1 more source
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
Nature reviews. Immunology, 2021 CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against pathogens and malignancies, and the molecular processes that lead to TRM cell formation are therefore of substantial biomedical interest. Prior work has demonstrated
Lianne Kok, D. Masopust, T. Schumacher
semanticscholar +1 more source
Cell Reports, 2017 SUMMARY Tissue-resident memory T cells (TRM) in mice mediate optimal protective immunity to infection and vaccination, while in humans, the existence and properties of TRM remain unclear.
Brahma V. Kumar +12 more
semanticscholar +1 more source
Gut tissue‐resident memory T cells in coeliac disease [PDF]
Scandinavian Journal of Immunology, 2021 AbstractThis mini‐review describes observations of the 1990ies with culturing of gluten‐specific and astrovirus‐specific CD4+ T cells from duodenal biopsies from subjects who presumably had a long time between the exposure to gluten or astrovirus antigens and the sampling of the biopsy.
openaire +4 more sources
Tissue-resident memory T cells in cytomegalovirus infection [PDF]
Current Opinion in Virology, 2016 Herpesviruses establish life-long infection in their hosts and maintain latent reservoirs for sporadic reactivation at peripheral sites, such as skin and mucosae. For herpes simplex virus infection, experimental studies in mice revealed that immediate protection against local reactivation or superinfection events in the skin relies on tissue resident ...
Thom Jenny Tosca, Oxenius Annette
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The Roles of Tissue-Resident Memory T Cells in Lung Diseases [PDF]
Frontiers in Immunology, 2021 The unique environment of the lungs is protected by complex immune interactions. Human lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen entry points and play an essential role in fighting against viral and bacterial pathogens at the frontline through direct mechanisms and also by orchestrating the adaptive immune ...
Rui Yuan +8 more
openaire +3 more sources
Tissue resident memory T cells inhabit the deep human conjunctiva
Scientific Reports, 2022 Mucosal linings of the body, including the conjunctiva, are enriched in tissue-resident memory T cells (TRMs) whose defining feature is their continual tissue protection that does not rely on migration to lymphoid organs to elicit immune responses ...
Racha Arnous +5 more
doaj +1 more source
Tissue resident memory T cells and viral immunity [PDF]
Current Opinion in Virology, 2017 Tissue resident memory T cells (TRM) constitute a recently identified T cell lineage that is responsible for frontline defense against viral infections. In contrast to central and effector memory T cells, which constitutively recirculate between tissues and blood, TRM reside permanently within tissues. As the main surveyors of non-lymphoid tissues, TRM
Pamela C, Rosato +2 more
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Location, location, location: Tissue resident memory T cells in mice and humans
Science immunology, 2019 This review summarizes key studies that have shaped our understanding of tissue resident memory T cells in mice and humans. The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity to encompass site-specific
P. Szabo, Michelle Miron, D. Farber
semanticscholar +1 more source