Results 61 to 70 of about 70,024 (278)

Isolation and Characterization of Human Tissue Resident Memory T cells. [PDF]

Curr Protoc
AbstractThe majority of immune cells in the human body exist within the tissues rather than in the circulation. Nevertheless, most of our knowledge of the human immune system is biased towards the characterization and understanding of circulating immune cell populations because the latter are readily sampled, whereas cells in tissues are difficult to ...
Jensen IJ, Wells SB, Gras J, Farber DL.
europepmc   +4 more sources

Monocyte-Derived Cells in Tissue-Resident Memory T Cell Formation [PDF]

The Journal of Immunology, 2020
Abstract There is currently much interest in how different dendritic cell and macrophage populations contribute to T cell–mediated immunity. Although conventional dendritic cell subsets have received much attention for their role in T cell priming, there is emerging evidence for a role for monocyte-derived APC (MoAPC) in tissue-resident ...
Kuan-Lun Chu, Nathália V Batista, Mélanie Girard, Tania H Watts   +3 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tissue-resident memory CD8+ T cells and their role in the immune response to infection and vaccination

Инфекция и иммунитет
A variety of body tissues contain tissue-resident memory CD8+ T cells — long-lived multifunctional effector cells formed during the immune response to infection, which populate previously infected tissue long term.
Vladimir Y. Talayev, Olga N. Babaykina, Maria V. Svetlova, Irina Y. Zaichenko, Elena V. Kurkova   +4 more
doaj   +1 more source

Knowns and unknowns of tissue‐resident memory T cells [PDF]

Immunology, 2019
SummaryAdvances in transcriptomics and other approaches are shedding considerable light on tissue‐resident immune cells as distinct from recirculating cells. The advances encompass antigen‐presenting cell subsets, Tregs and importantly, tissue‐resident memory cells (TRM).
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions.

Brain : a journal of neurology, 2020
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion activity declines.
N. Fransen, Cheng-Chih Hsiao, Marlijn van der Poel, Hendrik J. Engelenburg, Kim Verdaasdonk, M. C. Vincenten, E. Remmerswaal, T. Kuhlmann, M. Mason, J. Hamann, J. Smolders, I. Huitinga   +11 more
semanticscholar   +1 more source

CD8+ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network

eLife, 2023
CD8+ tissue-resident memory T (CD8+ Trm) cells play key roles in many immune-inflammation-related diseases. However, their characteristics in the pathological process of oral lichen planus (OLP) remains unclear. Therefore, we investigated the function of
Mao-Feng Qing, Dan Yang, Q. Shang, Jia-Kuan Peng, Jia-Qi Deng, Jian Lu, Jing Li, H. Dan, Yu Zhou, Hao Xu, Q. Chen   +10 more
semanticscholar   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Origins of CD8 tissue resident memory

Frontiers in Immunology
The concept that immune cells, specifically T cells, become established and reside in peripheral tissues, especially at barrier sites, has been around for several decades.
David J. Topham
doaj   +1 more source