Results 81 to 90 of about 70,024 (278)

Arthritis flares mediated by tissue-resident memory T cells in the joint

bioRxiv, 2021
Although rheumatoid arthritis is a systemic disease, flares typically occur in a subset of joints that is distinctive for each patient. Pursuing this intriguing pattern, we show that arthritis recurrence is mediated by long-lived synovial resident memory
Margaret H. Chang, A. Levescot, Nathan Nelson-Maney, Rachel B. Blaustein, K. Winden, Allyn Morris, Alexandra Wactor, Spoorthi Balu, Ricardo Grieshaber-Bouyer, Kevin Wei, L. Henderson, Y. Iwakura, R. Clark, Deepak A. Rao, R. Fuhlbrigge, P. Nigrovic   +15 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Langerhans Cells Directly Interact with Resident T Cells in the Human Epidermis

JID Innovations
Adult human skin contains nearly twice as many T cells as the peripheral blood, which include tissue-resident memory T cells. However, the precise mechanisms maintaining tissue-resident memory T cells in the healthy skin remain unclear.
Tomonori Oka, Tatsuya Hasegawa, Truelian Lee, Valeria S. Oliver-Garcia, Mahsa Mortaja, Marjan Azin, Satoshi Horiba, Sabrina S. Smith, Sara Khattab, Kathryn E. Trerice, Steven T. Chen, Yevgeniy R. Semenov, Shadmehr Demehri   +12 more
doaj   +1 more source

Bone marrow T cells and the integrated functions of recirculating and tissue-resident memory T cells

Frontiers in Immunology, 2016
Changes in T cell trafficking accompany the naïve to memory T cell antigen-driven differentiation, which remains an incompletely defined developmental step. Upon priming, each naïve T cell encounters essential signals–i.e.
Francesca eDi Rosa, Thomas eGebhardt
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway

Cell Reports, 2019
Summary: Non-recirculating tissue-resident memory T cells (TRMs) are the predominant T cell subset in diverse tissue sites, where they mediate protective immune responses in situ.
Stuart P. Weisberg, Dustin J. Carpenter, Michael Chait, Pranay Dogra, Robyn D. Gartrell-Corrado, Andrew X. Chen, Sean Campbell, Wei Liu, Pooja Saraf, Mark E. Snyder, Masaru Kubota, Nichole M. Danzl, Beth A. Schrope, Raul Rabadan, Yvonne Saenger, Xiaojuan Chen, Donna L. Farber   +16 more
doaj   +1 more source

Tissue-resident memory T cells and their function in skin diseases. [PDF]

Chin Med J (Engl)
Abstract Tissue-resident memory T (TRM) cells are a recently defined subtype of non-recirculating memory T cells with longevity and protective functions in peripheral tissues. As an essential frontline defense against infections, TRM cells have been reported to robustly patrol the tissue microenvironment in malignancies ...
Chen X, Zheng Y, Man X, Li W.
europepmc   +4 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)

Медицинская иммунология, 2018
Memory T cells are necessary for development of the immune response and represent one of the most numerous population of human T lymphocytes. On the contrary, suppressive regulatory T cells (Tregs) may terminate the immune response and help to maintain ...
E. K. Oleinik, A. V. Churov, V. M. Oleinik   +2 more
doaj   +1 more source

Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster

Nature Communications, 2022
T cells are considered important for controlling skin infections. Here, the authors report that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in rash-involved skin after recovery from zoster.
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle   +14 more
doaj   +1 more source