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Epigenetic control of tissue resident memory T cells [PDF]

Frontiers in Immunology
Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a ...
Zhiyi Lan, Zhiyi Lan, Zhiyi Lan, Zeyu Chen, Zeyu Chen, Nan Yang, Nan Yang, Tong Liu, Tong Liu, Siqi Li, Siqi Li, Yuling Shi, Yuling Shi, Jun Gu, Jun Gu   +14 more
doaj   +5 more sources

Tissue resident memory T cells populate the human uveal tract [PDF]

Scientific Reports
The current concept is that the eye is an immune privileged site endowed with innate immune regulatory networks to maintain organ function. We now have evidence that resident T cells occupy intraocular tissues.
Andrew D. Foers, Ian R. Reekie, Lakshanie C. Wickramasinghe, Amy Ward, Thomas MW. Buckley, Moustafa Attar, Soledad Aguilar-Munoa, Queen Pilapil, Maram EA. Abdalla Elsayed, Sam Pledger, Ananya Bhalla, Robert Hedley, Sarah Hill, Dylan Windell, Keith Barton, Imran Masood, Kin Sheng Lim, Mark C. Coles, Jonathan P. Sherlock, Andrew D. Dick, Sarah E. Coupland, Stephen N. Sansom, David A. Copland, Christopher D. Buckley, Srilakshmi M. Sharma, ORBIT Consortium   +25 more
doaj   +5 more sources

Tissue-Resident Memory T Cells in Cancer Metastasis Control [PDF]

Cells
Tissue-resident memory T (TRM) cells have emerged as critical sentinels in the control of cancer metastasis, yet their precise roles across different tumor types and tissues remain underappreciated.
Tyler H. Montgomery, Anuj P. Master, Zeng Jin, Qiongyu Shi, Qin Lai, Rohan Desai, Weizhou Zhang, Chandra K. Maharjan, Ryan Kolb   +8 more
doaj   +5 more sources

Tissue-resident memory T cells in urinary tract diseases [PDF]

Frontiers in Immunology
Tissue-resident memory T (TRM) cells are a specialized subset of memory T cells that permanently reside in non-lymphoid tissues, providing localized and long-lasting immune protection.
Guofeng Xu, Yuying Li, Yuying Li, Guanting Lu, Daoyuan Xie   +4 more
doaj   +4 more sources

Tissue‐resident memory T cells in diseases and therapeutic strategies [PDF]

MedComm
Tissue‐resident memory T (TRM) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, TRM cells are located within peripheral
Daoyuan Xie, Guanting Lu, Gang Mai, Qiuyan Guo, Guofeng Xu   +4 more
doaj   +4 more sources

Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. [PDF]

PLoS Pathogens, 2017
Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined.
Nelson D Glennie, Susan W Volk, Phillip Scott   +2 more
doaj   +2 more sources

CD8+ Tissue‐Resident Memory T Cells in Health and Disease [PDF]

MedComm
CD8+ tissue‐resident memory T (TRM) cells play a pivotal role in local immune regulation. These noncirculating T cells are uniquely positioned to orchestrate rapid site‐specific immune responses, making them central to understanding tissue‐specific ...
Yu‐Han Ai, Ting‐Ting Xu, Sen Lin, Meng‐Yu Xiao, Yun‐Xia Lin, Hao‐Wen Ma, Yue‐Yang Liu, Yao‐Jie Wang, Lu‐Ning Yin, Mei Huang, Yong‐Da Liu, Chao Zhu, Xiao‐Ting Zhu, Ji‐Hang Yuan   +13 more
doaj   +2 more sources

Tissue‐Resident Memory T Cells: Pioneering New Avenues in Cancer Immunotherapy [PDF]

Cancer Medicine
Background Tissue‐resident memory T cells (TRM) are a specialized subset of memory T cells that reside in nonlymphoid tissues and draining lymph nodes, playing a critical role in immune surveillance and tumor immunity.
Yao Xiao, Qi‐Chao Yang, Zhi‐Jun Sun
doaj   +2 more sources

Induction of tissue resident memory T cells by measles vaccine vector [PDF]

Human Vaccines & Immunotherapeutics
Measles live attenuated vaccine (MV) induces strong humoral and cellular systemic memory responses allowing the successful control of measles since decades.
Heidy Vera-Peralta, Claude Ruffié, Valérie Najburg, Matthias Brione, Chantal Combredet, Phanramphoei Frantz, Jean-Nicolas Tournier, Frédéric Tangy, Marie Mura   +8 more
doaj   +2 more sources

Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells

Frontiers in Immunology, 2021
CD8 positive, tissue resident memory T cells (TRM) are a specialized subset of CD8 memory T cells that surveil tissues and provide critical first-line protection against tumors and pathogen re-infection.
Curtis J. Pritzl, Mark A. Daniels, Emma Teixeiro   +2 more
doaj   +1 more source