Results 31 to 40 of about 17,677,818 (279)

Tissue-Specific Control of Tissue-Resident Memory T Cells [PDF]

Critical Reviews in Immunology, 2018
Tissue-resident memory T (TRM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts.
Yong, Liu, Chaoyu, Ma, Nu, Zhang
openaire   +2 more sources

Tissue-resident memory CD8(+)T cells shape local and systemic secondary T cell responses [PDF]

, 2020
Tissue-resident memory CD8(+)T cells (T(RM)cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear.
Arens, R., Parga-Vidal, L., Lier, R.A.W. van, Behr, F.M., Dam, T.J.P. van, Sheridan, B.S., Wesselink, T.H., Gisbergen, K.P.J.M. van, Kragten, N.A.M., Stark, R.   +9 more
core   +1 more source

Engineering Vaccines for Tissue‐Resident Memory T Cells

Advanced Therapeutics, 2021
Abstract In recent years, tissue‐resident memory T cells (T RM ) have attracted significant attention in the field of vaccine development. Distinct from central and effector memory T cells, T RM cells take up residence in home tissues ...
Frances C. Knight, John T. Wilson
openaire   +3 more sources

tissue‐resident memory T cells

, 2021
Brain CD8+ CD69+ tissue-resident memory T (TRM) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased.
Fransen, NL, Huitinga, I., Smolders, Joost; id_orcid, Hamann, J., Brandwijk, K.I.M., Hamann, J, Hsiao, C.-C., Joost Smolders, Brandwijk, KIM, Smolders, J., Jörg Hamann, Huitinga, I, van den Bosch, A.M.R., Hsiao, CC, Cheng‐Chih Hsiao, Aletta M.R. van den Bosch, Kim I.M. Brandwijk, Bosch, AMR, Nina L. Fransen, Fransen, N.L., Inge Huitinga   +20 more
core   +1 more source

Diverse functions of mucosal resident memory T cells [PDF]

, 2015
Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during
Kimberly Sue Schluns, Sue Schluns, Kimberly, Klonowski, Kim, Kim Klonowski   +3 more
core   +1 more source

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses [PDF]

, 2020
CD8+ tissue-resident memory T cells (TRM cells) are poised at the portals of infection and provide long-term protective immunity. Despite their critical roles, the precise mechanics governing TRM cell reactivation in situ are unknown.
Ruaidhri Jackson, Harman, Christian C. D., Shyer, Justin A., Maria Carolina Amezcua Vesely, Esen Sefik, Farsakoglu, Yagmur, Amezcua Vesely, Maria Carolina, Jiang, Xiaodong, Flavell, Richard A., Kaech, Susan M., Susan M. Kaech, Kelly, Joseph B., Christian C.D. Harman, Xiaodong Jiang, Yagmur Farsakoglu, Linda S. Cauley, Joseph B. Kelly, Cauley, Linda S., Sefik, Esen, Richard A. Flavell, Low, Jun Siong, Justin A. Shyer, Jackson, Ruaidhri, Jun Siong Low   +23 more
core   +1 more source

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

Cell Reports, 2020
Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionality in
Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini   +17 more
doaj   +1 more source

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites. [PDF]

Immunity
Lam N, Angel JC, Buchholz BA, Lee Y, Weisberg SP, Brown BH, Davis-Porada J, Caron DP, Jensen IJ, Szabo PA, Ural BB, Wells SB, Kubota M, Matsumoto R, Brusko M, Brusko TM, Lu C, Yates AJ, Farber DL.   +18 more
europepmc   +2 more sources

Tissue‐resident memory T cells and lung immunopathology

Immunological Reviews, 2023
SummaryRapid reaction to microbes invading mucosal tissues is key to protect the host against disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity against pathogen infection and/or re‐infection, due to their presence at the site of pathogen entry. However, there has been emerging evidence that exuberant TRM‐cell responses
In Su Cheon, Young Min Son, Jie Sun
openaire   +2 more sources

Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin

Cell Reports, 2019
Summary: Tissue-resident memory (TRM) CD8+ T cells are positioned within environmental barrier tissues to provide a first line of defense against pathogen entry, but whether these specialized T cell populations can be readily boosted to increase ...
Samuel J. Hobbs, Jeffrey C. Nolz
doaj   +1 more source