Results 21 to 30 of about 17,677,818 (279)

Tissue-resident memory T cells populate the human brain [PDF]

Nature Communications, 2018
Tissue-resident immune cells are important for local protections from pathogens. Here the authors show that brain tissue-resident memory T cells (TRM cells) can be further subsetted by CD103 expression, with higher CD103 correlates with increased ...
Joost Smolders, Kirstin M. Heutinck, Nina L. Fransen, Ester B. M. Remmerswaal, Pleun Hombrink, Ineke J. M. ten Berge, René A. W. van Lier, Inge Huitinga, Jörg Hamann   +8 more
doaj   +3 more sources

Divergent molecular networks program functionally distinct CD8+skin-resident memory T cells

, 2023
Skin-resident CD8+T cells include distinct interferon-g-producing [tissue-resident memory T type 1 (TRM1)] and interleukin-17 (IL-17)-producing (TRM17) subsets that differentially contribute to immune responses.
Kannourakis, George, Berzins, Stuart, Guillaume, Stephane, Wang, Huimeng, Zaid, Ali, Alexandre, Yannick, Evrard, Maximilien, Schröder, Jan, Davies, Brooke, Mueller, Scott, Carbone, Francis, Collins, Nicholas, Castellucci, Clara, Osman, Maleika, Park, Simone, Gandolfo, Luke, Mielke, Lisa, Belkaid, Yasmine, Han, Seong-Ji, Kallies, Axel, Mackay, Laura, Wells, Alexandria, Burn, Thomas, Speed, Terence, McDonald, Keely, Obers, Andreas, Christo, Susan, Zaid, A, Park, SL, Collins, N, Christo, SN, Evrard, M, Davies, B, Schröder, J, Han, SJ, Guillaume, SM, Burn, TN, Osman, M, Wells, AC, Castellucci, C, Gandolfo, LC, Alexandre, YO, et al.   +42 more
core   +3 more sources

Regulation of tissue-resident memory T cells by the Microbiota [PDF]

Mucosal Immunology, 2022
Resident memory T cells (Trms) predominantly reside within tissue and are critical for providing rapid protection against invasive viruses, fungi and bacteria. Given that tissues are heavily impacted and shaped by the microbiota, it stands to reason that Trms are also influenced by the microbiota that inhabits barrier sites.
Abigail E. Overacre-Delgoffe, Timothy W. Hand   +1 more
openaire   +2 more sources

Tissue-Resident Memory T Cells [PDF]

Immunity, 2014
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance.
Schenkel, Jason M., Masopust, David
openaire   +2 more sources

Tissue resident memory T cells in the respiratory tract [PDF]

Mucosal Immunology, 2022
Owing to their capacity to rapidly spread across the population, airborne pathogens represent a significant risk to global health. Indeed, several of the past major global pandemics have been instigated by respiratory pathogens. A greater understanding of the immune cells tasked with protecting the airways from infection will allow for the development ...
Zheng, Ming Z. M., Wakim, Linda M.
openaire   +2 more sources

Tissue‐resident memory T cells [PDF]

Immunological Reviews, 2013
SummaryTissues such as the genital tract, skin, and lung act as barriers against invading pathogens. To protect the host, incoming microbes must be quickly and efficiently controlled by the immune system at the portal of entry. Memory is a hallmark of the adaptive immune system, which confers long‐term protection and is the basis for efficacious ...
Haina, Shin, Akiko, Iwasaki
openaire   +2 more sources

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue. [PDF]

, 2021
Cross-reactive CD4+ T cells that recognize SARS-CoV-2 are more commonly detected in the peripheral blood of unexposed individuals compared to SARS-CoV-2-reactive CD8+ T cells.
Mazzurana, Luca,, Hodcroft, Emma B., Fehrm, Johan, Mjösberg, Jenny, Karlsson, Annika C., Maric, Jovana,, Lange, Joshua, Niessl, Julia,, Fehrm, Johan,, Forkel, Marianne, Price, David A, Lange, Joshua,, Buggert, Marcus,, Konya, Viktoria, Sundman, Joar, Konya, Viktoria,, Kokkinou, Efthymia,, Buggert, Marcus, Niessl, Julia, Mazzurana, Luca, Sundman, Joar,, Llewellyn-Lacey, Sian, Karlsson, Annika C.,, Kokkinou, Efthymia, Weigel, Whitney, Friberg, Danielle, Llewellyn-Lacey, Sian,, Mjösberg, Jenny,, Sekine, Takuya,, Sekine, Takuya, Price, David A.,, Friberg, Danielle,, Hodcroft, Emma B.,, Weigel, Whitney,, Rao, Anna,, Maric, Jovana, Karlsson, Annika C, Rao, Anna, Price, David A., Forkel, Marianne,, Niessl, J,, Forkel, M, Maric, J, Mazzurana, L, Rao, A, Kokkinou, E, Weigel, W, Konya, V, Sekine, T,, Lange, J, Takuya Sekine, Marianne Forkel, Anna Rao, Joshua Lange, Danielle Friberg, David A. Price, Joar Sundman, Marcus Buggert, Viktoria Konya, Jovana Maric, Luca Mazzurana, Julia Niessl, Emma B. Hodcroft, Jenny Mjösberg, Whitney Weigel, Annika C. Karlsson, Efthymia Kokkinou, Sian Llewellyn-Lacey, Johan Fehrm   +68 more
core   +2 more sources

Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis

Frontiers in Immunology, 2023
Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably reside in tissues and have been revealed to be the most abundant memory T cell population in various tissues.
Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan, Xiaofei Shen   +4 more
doaj   +1 more source

Tissue-Resident T Cells in Chronic Relapsing–Remitting Intestinal Disorders [PDF]

, 2021
Tissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also
Christoph Mueller, Mueller, Christoph, Barreto de Albuquerque, Juliana, Gungor, Bilgi, Juliana Barreto de Albuquerque, de Albuquerque, Juliana Barreto, Bilgi Gungor   +6 more
core   +3 more sources

Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability

Journal for ImmunoTherapy of Cancer, 2023
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome
Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji   +9 more
doaj   +1 more source