Results 51 to 60 of about 70,024 (278)
Formation of Tissue-Resident CD8+ T-Cell Memory [PDF]
Cold Spring Harbor Perspectives in Biology, 2021 Resident memory CD8+ T (Trm) cells permanently reside in nonlymphoid tissues where they act as a first line of defense against recurrent pathogens. How and when antigen-inexperienced CD8+ T cells differentiate into Trm has been a topic of major interest, as knowledge on how to steer this process may be exploited in the development of vaccines and ...
Feline E, Dijkgraaf +2 more
openaire +2 more sources
Nature Communications, 2016 Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not
Haina Shin +3 more
doaj +1 more source
Tissue-resident memory-like ILCs: innate counterparts of TRM cells
Protein & Cell, 2019 Innate lymphoid cells (ILCs) are defined as lymphocytes that lack RAG recombinase and do not express diverse antigen receptors; however, recent studies have revealed the adaptive features of ILCs. Mouse cytomegalovirus (MCMV)- and cytokine-induced memory
Xianwei Wang, Zhigang Tian, Hui Peng
doaj +1 more source
Generation and persistence of human tissue-resident memory T cells in lung transplantation
Science immunology, 2019 Human tissue-resident memory T cells persist long term in transplanted lungs and develop from infiltrating recipient T cells. Transplanted memories Parabiosis experiments in mice have shaped our understanding of the tissue retention properties of tissue ...
M. Snyder +19 more
semanticscholar +1 more source
Tissue-resident memory T cells orchestrate tumour-immune equilibrium
Cell Stress, 2019 The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune cells such as T cells restrict tumour growth either by completely eradicating cancer cells in a process of ‘elimination’ or by
Simone L. Park +3 more
doaj +1 more source
Tissue Adaptations of Memory and Tissue-Resident Gamma Delta T Cells
Frontiers in Immunology, 2018 Epithelial and mucosal barriers are critical interfaces physically separating the body from the outside environment and are the tissues most exposed to microorganisms and potential inflammatory agents.
Camille Khairallah +2 more
doaj +1 more source
IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection
Nature Communications, 2023 CD8+ T cell tissue resident memory (TRM) cells are especially suited to control pathogen spread at mucosal sites. However, their maintenance in lung is short-lived. TCR-dependent NFkB signaling is crucial for T cell memory but how and when NFkB signaling
Curtis J. Pritzl +6 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies
EMBO Molecular Medicine, 2023 Idiopathic inflammatory myopathies (IIM) are rare autoimmune systemic diseases characterized by muscle weakness and the presence of muscle‐infiltrating T cells.
Alexandra Argyriou +13 more
doaj +1 more source
Cells, 2022 Studying functionality and antigen-specificity of resident kidney T cells derived from a kidney biopsy is hampered by the lack of sufficient numbers of T cells obtained by the standard method of enzymatic tissue dissociation.
Michiel G. H. Betjes +4 more
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