Results 31 to 40 of about 70,024 (278)

Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. [PDF]

PLoS Pathogens, 2017
Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined.
Nelson D Glennie, Susan W Volk, Phillip Scott   +2 more
doaj   +1 more source

Tissue-resident memory T cells in the kidney

Seminars in Immunopathology, 2022
Abstract The identification of tissue-resident memory T cells (T RM cells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that T RM cells are induced after an acute T-cell ...
Nariaki Asada, Pauline Ginsberg, Nicola Gagliani, Hans-Willi Mittrücker, Ulf Panzer   +4 more
openaire   +2 more sources

Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis

Frontiers in Immunology, 2023
Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably reside in tissues and have been revealed to be the most abundant memory T cell population in various tissues.
Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan, Xiaofei Shen   +4 more
doaj   +1 more source

Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis

Gastroenterology, 2021
Background & Aims The pathogenesis of immune checkpoint inhibitor (ICI)–colitis remains incompletely understood. We sought to identify key cellular drivers of ICI-colitis and their similarities to idiopathic ulcerative colitis, and to determine potential
S. Sasson, S. Slevin, V. Cheung, I. Nassiri, A. Olsson-Brown, E. Fryer, R. Ferreira, D. Trzupek, T. Gupta, L. Al‐Hillawi, Mari-Lenna Issaias, A. Easton, L. Campo, M. FitzPatrick, Joss Adams, M. Chitnis, A. Protheroe, M. Tuthill, N. Coupe, A. Simmons, M. Payne, M. Middleton, S. Travis, B. Fairfax, P. Klenerman, O. Brain   +25 more
semanticscholar   +1 more source

Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability

Journal for ImmunoTherapy of Cancer, 2023
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome
Qi Zhang, Jiangchao Wu, Tingbo Liang, Xueli Bai, Xun Wang, Jianpeng Sheng, Junlei Zhang, Jianghui Tang, Jinyuan Song, Yongtao Ji   +9 more
doaj   +1 more source

CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells

Nature Communications, 2021
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but the cellular and molecular mechanisms underlying NASH resolution
Yuzo Koda, Toshiaki Teratani, Po-Sung Chu, Yuya Hagihara, Y. Mikami, Yosuke Harada, H. Tsujikawa, K. Miyamoto, Takahiro Suzuki, N. Taniki, T. Sujino, M. Sakamoto, T. Kanai, N. Nakamoto   +13 more
semanticscholar   +1 more source

Engineering Vaccines for Tissue‐Resident Memory T Cells

Advanced Therapeutics, 2021
Abstract In recent years, tissue‐resident memory T cells (T RM ) have attracted significant attention in the field of vaccine development. Distinct from central and effector memory T cells, T RM cells take up residence in home tissues ...
Frances C. Knight, John T. Wilson
openaire   +3 more sources

The evolving role of tissue-resident memory T cells in infections and cancer

Science Advances, 2022
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in tissues. TRM form an integral part of the immune sensing network and have the ability to control local immune homeostasis and participate in immune responses ...
Sasitorn Yenyuwadee, Jose Luis Sanchez-Trincado Lopez, R. Shah, Pamela C. Rosato, V. Boussiotis   +4 more
semanticscholar   +1 more source

Tissue‐resident memory T cells and lung immunopathology

Immunological Reviews, 2023
SummaryRapid reaction to microbes invading mucosal tissues is key to protect the host against disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity against pathogen infection and/or re‐infection, due to their presence at the site of pathogen entry. However, there has been emerging evidence that exuberant TRM‐cell responses
In Su Cheon, Young Min Son, Jie Sun
openaire   +2 more sources

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

Cell Reports, 2020
Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionality in
Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini   +17 more
doaj   +1 more source