Results 21 to 30 of about 57,318 (251)
Heterogeneity of tissue resident memory T cells
Immunology Letters, 2022 Non-lymphoid organs, in mice and humans, contain CD8+ tissue-resident memory T (TRM) cells. They play important roles in tissue homoeostasis as well as defence against infections and cancer. TRM cells have common characteristics that enables their tissue residency and function.
Špela Konjar +3 more
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Resident memory T cells and cancer. [PDF]
ImmunityTissue-resident memory T (TRM) cells positively correlate with cancer survival, but the anti-tumor mechanisms underlying this relationship are not understood. This review reconciles these observations, summarizing concepts of T cell immunosurveillance, fundamental TRM cell biology, and clinical observations on the role of TRM cells in cancer and ...
Gavil NV, Cheng K, Masopust D.
europepmc +3 more sources
Tissue-resident memory T cells in the kidney
Seminars in Immunopathology, 2022 Abstract The identification of tissue-resident memory T cells (T RM cells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that T RM cells are induced after an acute T-cell ...
Nariaki Asada +4 more
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Cell Reports, 2023 Summary: The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of CD4+ T cells; however, its cell-intrinsic role in CD8+ T cells remains elusive.
Joseph W. Dean +8 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2023 Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive tumor microenvironment. To date, attempts to overcome
Qi Zhang +9 more
doaj +1 more source
Frontiers in Immunology, 2018 BackgroundResident memory T cells have emerged as key players in the immune response generated against a number of pathogens. Their ability to take residence in non-lymphoid peripheral tissues allows for the rapid deployment of secondary effector ...
Visai Muruganandah +4 more
doaj +1 more source
SnapShot: Resident Memory T Cells
Cell, 2014 Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re-encountered at these locales, thereby accelerating protective immune responses.
Beura, Lalit K., Masopust, David
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Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin
Cell Reports, 2019 Summary: Tissue-resident memory (TRM) CD8+ T cells are positioned within environmental barrier tissues to provide a first line of defense against pathogen entry, but whether these specialized T cell populations can be readily boosted to increase ...
Samuel J. Hobbs, Jeffrey C. Nolz
doaj +1 more source
Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. [PDF]
PLoS ONE, 2011 Recent studies have shown that tissue resident memory T cells (T(RM)) are critical to antiviral host defense in peripheral tissues. This new appreciation of T(RM) that reside in epithelial tissues and mediate host defense has been studied most ...
Rahul Purwar +5 more
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Discipline in Stages: Regulating CD8+ Resident Memory T Cells
Frontiers in Immunology, 2021 Resident memory CD8+ T (TRM) cells are a lymphocyte lineage distinct from circulating memory CD8+ T cells. TRM lodge within peripheral tissues and secondary lymphoid organs where they provide rapid, local protection from pathogens and control tumor ...
Rut Mora-Buch, Shannon K. Bromley
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