Results 31 to 40 of about 57,318 (251)

Resident Memory T Cells and Their Role within the Liver [PDF]

International Journal of Molecular Sciences, 2020
Immunological memory is fundamental to maintain immunity against re-invading pathogens. It is the basis for prolonged protection induced by vaccines and can be mediated by humoral or cellular responses—the latter largely mediated by T cells. Memory T cells belong to different subsets with specialized functions and distributions within the body.
Ghilas, S, Valencia-Hernandez, AM, Enders, MH, Heath, WR, Fernandez-Ruiz, D, Fernandez Ruiz, Daniel   +5 more
openaire   +3 more sources

Memory regulatory T cells reside in human skin [PDF]

Journal of Clinical Investigation, 2014
Regulatory T cells (Tregs), which are characterized by expression of the transcription factor Foxp3, are a dynamic and heterogeneous population of cells that control immune responses and prevent autoimmunity. We recently identified a subset of Tregs in murine skin with properties typical of memory cells and defined this population as memory Tregs ...
Sanchez Rodriguez, Robert, Pauli, Mariela L, Neuhaus, Isaac M, Yu, Siegrid S, Arron, Sarah T, Harris, Hobart W, Yang, Sara Hsin-Yi, Anthony, Bryan A, Sverdrup, Francis M, Krow-Lucal, Elisabeth, MacKenzie, Tippi C, Johnson, David S, Meyer, Everett H, Löhr, Andrea, Hsu, Andro, Koo, John, Liao, Wilson, Gupta, Rishu, Debbaneh, Maya G, Butler, Daniel, Huynh, Monica, Levin, Ethan C, Leon, Argentina, Hoffman, William Y, McGrath, Mary H, Alvarado, Michael D, Ludwig, Connor H, Truong, Hong-An, Maurano, Megan M, Gratz, Iris K, Abbas, Abul K, Rosenblum, Michael D   +31 more
openaire   +4 more sources

Tissue resident memory T cells in the respiratory tract [PDF]

Mucosal Immunology, 2022
Owing to their capacity to rapidly spread across the population, airborne pathogens represent a significant risk to global health. Indeed, several of the past major global pandemics have been instigated by respiratory pathogens. A greater understanding of the immune cells tasked with protecting the airways from infection will allow for the development ...
Zheng, Ming Z. M., Wakim, Linda M.
openaire   +2 more sources

Characterization of human epithelial resident memory regulatory T cells

Frontiers in Immunology, 2022
Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin.
Takuya Sato, Youichi Ogawa, Kazunori Yokoi, Yuka Nagasaka, Aoha Ishikawa, Ichiro Shiokawa, Manao Kinoshita, Rei Watanabe, Shinji Shimada, Atsushi Tanaka, Akira Momosawa, Tatsuyoshi Kawamura   +11 more
doaj   +1 more source

Engineering Vaccines for Tissue‐Resident Memory T Cells

Advanced Therapeutics, 2021
Abstract In recent years, tissue‐resident memory T cells (T RM ) have attracted significant attention in the field of vaccine development. Distinct from central and effector memory T cells, T RM cells take up residence in home tissues ...
Frances C. Knight, John T. Wilson
openaire   +3 more sources

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

Nature Communications, 2016
Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not
Haina Shin, Yosuke Kumamoto, Smita Gopinath, Akiko Iwasaki   +3 more
doaj   +1 more source

Integrating resident memory into T cell differentiation models

Current Opinion in Immunology, 2020
Advances in the field of T cell memory, including the discovery of tissue residency, continue to add to the list of defined T cell subsets. Here, we briefly review the role of resident memory T cells (TRM) in protective immunity, and propose that they exhibit developmental and migrational plasticity.
Pamela C Rosato, Sathi Wijeyesinghe, J Michael Stolley, David Masopust   +3 more
openaire   +3 more sources

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites. [PDF]

Immunity
Lam N, Angel JC, Buchholz BA, Lee Y, Weisberg SP, Brown BH, Davis-Porada J, Caron DP, Jensen IJ, Szabo PA, Ural BB, Wells SB, Kubota M, Matsumoto R, Brusko M, Brusko TM, Lu C, Yates AJ, Farber DL.   +18 more
europepmc   +2 more sources

Liver-resident memory T cells: life in lockdown

Seminars in Immunopathology, 2022
AbstractA subset of memory T cells has been identified in the liver with a tissue-resident profile and the capacity for long-term ‘lockdown’. Here we review how they are retained in, and adapted to, the hepatic microenvironment, including its unique anatomical features and metabolic challenges.
Laura J. Pallett, Mala K. Maini
openaire   +3 more sources

CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice

Mediators of Inflammation, 2019
The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and ...
Kang Wu, Fei Wang, Guangwu Guo, Yuqing Li, Li-Jun Qiu, Xuefeng Li   +5 more
doaj   +1 more source