Results 41 to 50 of about 57,318 (251)
mBio, 2016 Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), yet its moderate efficacy against pulmonary TB calls for improved vaccination strategies.
Carolina Perdomo +8 more
doaj +1 more source
Tissue-resident memory T cells in renal autoimmune diseases
Frontiers in Immunology, 2023 The discovery of tissue-resident memory T cells (TRM cells) reinterpreted the potential of human tissue-specific immunity. Following T cell receptor (TCR) activation and clonal expansion, effector T cells migrate to peripheral tissues where they remain ...
Pauline Ginsberg +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Инфекция и иммунитетA variety of body tissues contain tissue-resident memory CD8+ T cells — long-lived multifunctional effector cells formed during the immune response to infection, which populate previously infected tissue long term.
Vladimir Y. Talayev +4 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Resident memory T cells in mouse and human
Japanese Journal of Clinical Immunology, 2016 Recent researches are revealing the importance of a new subset of memory T cells called resident memory T cells (TRMs). Once they enter the tissues according to their tissue-homing receptors, TRMs do not go back to circulation and stay in the same tissues for a long time.
openaire +3 more sources
Origins of CD8 tissue resident memory
Frontiers in ImmunologyThe concept that immune cells, specifically T cells, become established and reside in peripheral tissues, especially at barrier sites, has been around for several decades.
David J. Topham
doaj +1 more source
Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity
Frontiers in Immunology, 2020 Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV ...
Chek Meng Poh +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Tissue-resident memory-like ILCs: innate counterparts of TRM cells
Protein & Cell, 2019 Innate lymphoid cells (ILCs) are defined as lymphocytes that lack RAG recombinase and do not express diverse antigen receptors; however, recent studies have revealed the adaptive features of ILCs. Mouse cytomegalovirus (MCMV)- and cytokine-induced memory
Xianwei Wang, Zhigang Tian, Hui Peng
doaj +1 more source