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Immunology
AbstractPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis
Guoshu Deng +10 more
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AbstractPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis
Guoshu Deng +10 more
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Clinical Scale Central Memory T Cell Enrichment for Adoptive T Cell Therapy
Blood, 2010Abstract Abstract 5180 The adoptive transfer of genetically engineered lymphocytes is a promising strategy to treat cancer. However, the efficacy of adoptive immunotherapy in humans is often limited and the critical parameters for the in vivo efficacy remain poorly defined.
Anna Casati +7 more
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Trends in Immunology, 2007
The ability of the immune system to 'remember' a previous encounter with antigen is the hallmark of the adaptive immune response. The signals required for CD4(+) memory T cell survival are not well understood, and a recent paper lends new biochemical insights into how memory T cells might optimally be preserved through the convergence of signals from ...
Caserta, Stefano, Zamoyska, Rose
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The ability of the immune system to 'remember' a previous encounter with antigen is the hallmark of the adaptive immune response. The signals required for CD4(+) memory T cell survival are not well understood, and a recent paper lends new biochemical insights into how memory T cells might optimally be preserved through the convergence of signals from ...
Caserta, Stefano, Zamoyska, Rose
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Increased CD8+ central memory T cells in patients with multiple sclerosis
Multiple Sclerosis Journal, 2007AT-cell-mediated autoimmune process against central nervous system myelin is believed to underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is based on the differentiation of naïve T cells to memory T cells after exposure to antigens and specific cytokines.
Guang-Zhi, Liu +3 more
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Cancer Research, 2022
Abstract Stem memory T cells (Tscm) are integral for effective immunotherapy and antitumor responses, but little is known about Tscm immunobiology in solid human tumors. Here we identify self-renewing and multipotent Tscm tumor-infiltrating lymphocytes (TILs) in human cancer and present a novel Tscm subset which expresses CD45RO, is ...
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Abstract Stem memory T cells (Tscm) are integral for effective immunotherapy and antitumor responses, but little is known about Tscm immunobiology in solid human tumors. Here we identify self-renewing and multipotent Tscm tumor-infiltrating lymphocytes (TILs) in human cancer and present a novel Tscm subset which expresses CD45RO, is ...
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[Research progress on central memory T cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunologyCentral memory T (Tcm) cells are a crucial subset in T cell development, playing an important role in long-term immune responses. Tcm cells exhibit strong proliferative capacity, long-term survival characteristics, and re-activation potential, enabling them to rapidly differentiate into effector T cells (Teff) upon antigen re-exposure, thus providing ...
Junwei, Huang +6 more
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Deciphering the relationship between central and effector memory CD8+ T cells
Trends in Immunology, 2003Abstract Memory CD8 + T cells can be divided into subpopulations termed central memory cells and effector memory cells based on their phenotype and potential to home to lymph nodes versus non-lymphoid tissues, respectively. Two recent studies, one in humans and one in mice, provide new insight into the lineage relationship between these ...
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Brain and Other Central Nervous System Tumor Statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021Rebecca L. Siegel +2 more
exaly
Generation and function of mouse central memory and effector memory T cells
20071. SUMMARY Based on functional and homing properties, two subsets of memory T lymphocytes have been defined both in humans and in mice. Central memory T cells (TCM cells) express the lymph node homing receptors CD62L and CCR7, have poor effector function and proliferate efficiently upon antigenic stimulation.
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