Results 111 to 120 of about 3,023,998 (402)

Short and random: Modelling the effects of (proto-)neural elongations [PDF]

, 2017
To understand how neurons and nervous systems first evolved, we need an account of the origins of neural elongations: Why did neural elongations (axons and dendrites) first originate, such that they could become the central component of both neurons and ...
de Wiljes, Oltman O., Keijzer, Fred A., van Elburg, Ronald A. J.   +2 more
core   +3 more sources

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

DAPT, a γ-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling

Frontiers in Oncology, 2019
Advances in the understanding of growth hormone-producing adenomas (GHomas) are ongoing, but current therapy is limited by moderate and variable efficacy and in need of life-long treatment.
Jie Feng, Jianpeng Wang, Qian Liu, Jiye Li, Qi Zhang, Zhengping Zhuang, Xiaohui Yao, Chunhui Liu, Yangfang Li, Lei Cao, Chuzhong Li, Lei Gong, Dan Li, Yazhuo Zhang, Hua Gao   +14 more
doaj   +1 more source

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Journal of Neuroinflammation, 2019
Development of central nervous system (CNS) is regulated by both intrinsic and peripheral signals. Previous studies have suggested that environmental factors affect neurological activities under both physiological and pathological conditions.
Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y Wang, Qing Liu, Rong-Fu Wang   +5 more
semanticscholar   +1 more source

Lipotropin and the Central Nervous System

, 1977
Publisher Summary This chapter deals with the interaction of the lipotropin fragments and related peptides with the central nervous system (CNS). Peptides containing ACTH 4-10, in general, stimulate firing rate, excitability of neurons and neurotransmission, increase cAMP levels, and counteract some morphine-induced CNS effects (inhibition of spinal ...
Gispen, W.H., Ree, J.M. van, Wied, D. de
openaire   +4 more sources

Performance of Composite Endpoints Defining Progression Independent of Relapse Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The characteristics and utility of composite progression independent of relapse activity (cPIRA; worsening on the Expanded Disability Status Scale [EDSS], or 9‐Hole Peg Test, or Timed 25‐Foot Walk Test) were evaluated as an endpoint in relapsing multiple sclerosis (RMS) trials using the ENSEMBLE (NCT03085810) and pooled OPERA I/II ...
Ludwig Kappos, Sean Yiu, Jason Reucassel, Jiwon Oh, Cristina Granziera, Joep Killestein, Robert A. Bermel, Claude Berge, Agne Kazlauskaite, Hans‐Martin Schneble, Frank Dahlke, Bruce A. C. Cree   +11 more
wiley   +1 more source

Myelin in the Central Nervous System: Structure, Function, and Pathology.

Physiological Reviews, 2019
Oligodendrocytes generate multiple layers of myelin membrane around axons of the central nervous system to enable fast and efficient nerve conduction.
C. Stadelmann, Sebastian Timmler, A. Barrantes-Freer, M. Simons   +3 more
semanticscholar   +1 more source

Tuberculosis of the central nervous system [PDF]

Postgraduate Medical Journal, 1999
Summary Tuberculous involvement of the brain and spinal cord are common neurological disorders in developing countries and have recently shown a resurgence in developed ones. Tuberculous meningitis is an important manifestation and is associated with high morbidity and mortality.
openaire   +3 more sources

Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro, Manuela Dicarlo, Chiara Zecca, Daniele Urso, Maria Teresa Dell'Abate, Davide Vilella, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Maria Grano, Giancarlo Logroscino   +12 more
wiley   +1 more source

Niche stiffness underlies the aging of central nervous system progenitor cells

Nature, 2019
Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell and progenitor cell populations1. One example is the deterioration of the regenerative capacity of the widespread and abundant population of central nervous ...
Michael Segel, Björn Neumann, M. Hill, Isabell P. Weber, C. Viscomi, Chao Zhao, Adam M. H. Young, Chibeza C. Agley, Amelia J Thompson, G. Gonzalez, Amar Sharma, S. Holmqvist, D. Rowitch, K. Franze, R. Franklin, K. Chalut   +15 more
semanticscholar   +1 more source