Results 111 to 120 of about 3,233,933 (403)

Central Nervous System Tuberculoma [PDF]

The American Journal of Tropical Medicine and Hygiene, 2021
Cataño, Juan, Porras, Jessica
openaire   +2 more sources

Short and random: Modelling the effects of (proto-)neural elongations [PDF]

, 2017
To understand how neurons and nervous systems first evolved, we need an account of the origins of neural elongations: Why did neural elongations (axons and dendrites) first originate, such that they could become the central component of both neurons and ...
de Wiljes, Oltman O., Keijzer, Fred A., van Elburg, Ronald A. J.   +2 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation

Frontiers in Immunology
ObjectiveTo elucidate causal roles of circulating immune cells and plasma proteins in diabetic peripheral neuropathy (DPN) pathogenesis using integrative Mendelian randomization (MR) and single-cell validation.MethodsWe employed two-sample MR to assess ...
Chenhao Hu, Shengqiao Sun, Dezhi Li, Dezhi Li, Lebao Yu, Chao Guo, Song Liu, Song Liu, Song Liu   +8 more
doaj   +1 more source

A zinc transporter gene required for development of the nervous system. [PDF]

, 2013
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous ...
Chowanadisai, Winyoo, Graham, David M, Keen, Carl L, Messerli, Mark A, Rucker, Robert B   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

DAPT, a γ-Secretase Inhibitor, Suppresses Tumorigenesis, and Progression of Growth Hormone-Producing Adenomas by Targeting Notch Signaling

Frontiers in Oncology, 2019
Advances in the understanding of growth hormone-producing adenomas (GHomas) are ongoing, but current therapy is limited by moderate and variable efficacy and in need of life-long treatment.
Jie Feng, Jianpeng Wang, Qian Liu, Jiye Li, Qi Zhang, Zhengping Zhuang, Xiaohui Yao, Chunhui Liu, Yangfang Li, Lei Cao, Chuzhong Li, Lei Gong, Dan Li, Yazhuo Zhang, Hua Gao   +14 more
doaj   +1 more source

The Effect of Toluene Exposure on Central Nervous Disorder Among Printing Workers [PDF]

, 2018
Background: The use of toluene in printing dominates the use of metal chemicals. Toluene is used in 75% of printing work activities. Accumulation of toluene concentrations in printing can cause health problems to workers. The purpose of this study was to
Ashar, T. (Taufik), Marganda, S. (Samuel), Nurmaini, N. (Nurmaini)   +2 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Niche stiffness underlies the aging of central nervous system progenitor cells

Nature, 2019
Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell and progenitor cell populations1. One example is the deterioration of the regenerative capacity of the widespread and abundant population of central nervous ...
Michael Segel, Björn Neumann, M. Hill, Isabell P. Weber, C. Viscomi, Chao Zhao, Adam M. H. Young, Chibeza C. Agley, Amelia J Thompson, G. Gonzalez, Amar Sharma, S. Holmqvist, D. Rowitch, K. Franze, R. Franklin, K. Chalut   +15 more
semanticscholar   +1 more source