Results 121 to 130 of about 2,021,144 (357)

Observational Study of Tocilizumab in Children With Febrile Infection‐Related Epilepsy Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to assess the efficacy and safety of using tocilizumab in children with febrile infection‐related epilepsy syndrome (FIRES) and explore tocilizumab‐related changes in interleukin (IL)‐6 levels. Methods Patients with FIRES admitted to the Intensive Care Unit (ICU) of Beijing Children's Hospital were retrospectively ...
Yushan He   +7 more
wiley   +1 more source

Research and application progress of MGMT promoter methylation in gliomas

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2014
O6-methylguanine-DNA methyltransferase (MGMT) is an important DNA repair enzyme. The promoter methylation status of MGMT gene has recently become a biomarker of gliomas.
Cui-yun SUN, Shi-zhu YU
doaj  

Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR

open access: yesCommunications Biology
Hypoxia is a common feature of glioblastoma (GBM). Circular RNAs (circRNAs) are identified as regulators in cancers. However, the role of circRNAs in GBM remains elusive.
Aixin Yu   +14 more
doaj   +1 more source

Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)–associated disease (MOGAD). Methods One‐hundred‐nine paediatric MOGAD patients from two UK centres underwent MRI at attack nadir and ...
Ermelinda De Meo   +14 more
wiley   +1 more source

Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury

open access: yesRedox Biology
Traumatic brain injury (TBI) triggers a robust inflammatory response that is closely linked to worsened clinical outcomes. S100A8/A9, also known as calprotectin or myeloid-related protein-8/14 (MRP8/14), is an alarmin primarily secreted by activated ...
Guihong Shi   +16 more
doaj  

Effectiveness and safety of single anti-seizure medication as adjunctive therapy for drug-resistant focal epilepsy based on network meta-analysis

open access: yesFrontiers in Pharmacology
ObjectiveTo evaluated the effectiveness and safety of single anti-seizure medication (ASM) when used as adjunctive therapy for drug-resistant focal epilepsy.MethodsWe conducted a comprehensive search of PubMed, EMbase, and the Cochrane Library from their
Nian-Jia Deng   +12 more
doaj   +1 more source

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

open access: yesActa Neuropathologica, 2016
D. Louis   +9 more
semanticscholar   +1 more source

High‐Efficacy Treatment in Neuromyelitis Optica Specturm Disorder Patients With Seropositive AQP4 Antibodies—A Real‐World Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the effectiveness of high‐efficacy treatments (HET) and low‐efficacy treatments (LET) in NMOSD patients with anti‐aquaporin‐4 antibodies (AQP4‐ab). Methods In this multi‐center study, we analyzed 183 AQP4‐ab seropositive NMOSD patients who received immunosuppressive treatments (IST).
Xiang Li   +10 more
wiley   +1 more source

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