Results 1 to 10 of about 1,317,105 (347)

Bioavailable central nervous system disease-modifying therapies for multiple sclerosis [PDF]

Frontiers in Immunology, 2023
Disease-modifying therapies for relapsing multiple sclerosis reduce relapse rates by suppressing peripheral immune cells but have limited efficacy in progressive forms of the disease where cells in the central nervous system play a critical role.
Hans-Peter Hartung, Hans-Peter Hartung, Hans-Peter Hartung, Hans-Peter Hartung, Bruce A.C. Cree, Michael Barnett, Sven G. Meuth, Amit Bar-Or, Lawrence Steinman   +8 more
doaj   +2 more sources

Central nervous system commitment in Chagas disease

Frontiers in Immunology, 2022
The involvement of the central nervous system (CNS) during human acute and chronic Chagas disease (CD) has been largely reported. Meningoencephalitis is a frequent finding during the acute infection, while during chronic phase the CNS involvement is ...
Yerly Useche, Ana Rosa Pérez, Ana Rosa Pérez, Juliana de Meis, Juliana de Meis, Juliana de Meis, Adriana Bonomo, Adriana Bonomo, Adriana Bonomo, Wilson Savino, Wilson Savino, Wilson Savino   +11 more
doaj   +4 more sources

Clinical significance of occult central nervous system disease in adult acute lymphoblastic leukemia. A multicenter report from the Campus ALL Network [PDF]

Haematologica, 2019
In acute lymphoblastic leukemia, flow cytometry detects more accurately leukemic cells in patients' cerebrospinal fluid compared to conventional cytology.
Maria Ilaria Del Principe, Elisa Buzzatti, Alfonso Piciocchi, Fabio Forghieri, Massimiliano Bonifacio, Federica Lessi, Silvia Imbergamo, Enrico Orciuolo, Giovanni Rossi, Nicola Fracchiolla, Silvia Trappolini, Benedetta Neri, Chiara Sarlo, Patrizia Zappasodi, Michelina Dargenio, Mariagiovanna Cefalo, Maria Antonietta Irno-Consalvo, Consuelo Conti, Giovangiacinto Paterno, Gottardo De Angelis, Mariarita Sciumè, Irene Della Starza, Adriano Venditti, Robin Foà, Anna Rita Guarini   +24 more
doaj   +2 more sources

Disulfidptosis: a new target for central nervous system disease therapy [PDF]

Frontiers in Neuroscience
Disulfidptosis is a pathologic process that occurs under conditions of NADPH deficiency and excess disulfide bonds in cells that express high levels of SLC7A11.
Jing Chang, Danhong Liu, Danhong Liu, Yuqi Xiao, Boyao Tan, Jun Deng, Zhigang Mei, Jun Liao, Jun Liao   +8 more
doaj   +2 more sources

MicroRNAs of microglia: Wrestling with central nervous system disease [PDF]

Neural Regeneration Research, 2018
Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation.
Xiao-Hua Wang, Tian-Long Wang
doaj   +2 more sources

Cystatin F-a key player in central nervous system disease [PDF]

Journal of Neuroinflammation
Cystatin F is an endogenous cysteine protease inhibitor that belongs to the type II cystatin family. It has several unique characteristic structures that determine some of its specific functions. Cystatin F is expressed predominantly in peripheral immune
Yi-Ting Wang, Qiang Li, Jun-Chao Liu, Chen Chen, He-Xuan Ding, Xu Zha, Ke Zhang   +6 more
doaj   +2 more sources

Central nervous system vasculopathy caused by Fabry disease: a case report [PDF]

BMC Neurology, 2019
Background Fabry disease is rare, and the diagnosis is often delayed. Here, we describe a case of Fabry disease resulting in vasculopathy of the central nervous system.
De-Zheng Kong, Ya-Hui Lian, Lin-Jing Wang, Chun-Mei Wang, Yang-Yang Meng, Hong-Wei Zhou   +5 more
doaj   +2 more sources

Air Pollution and Central Nervous System Disease: A Review of the Impact of Fine Particulate Matter on Neurological Disorders. [PDF]

Front Public Health, 2020
Kim H, Kim WH, Kim YY, Park HY.
europepmc   +3 more sources

Treatment and mortality outcomes in patients with other extrapulmonary cryptococcal disease compared with central nervous system disease. [PDF]

Mycoses, 2021
Mejia-Chew C, Sung A, Larson L, Powderly WG, Spec A.   +4 more
europepmc   +3 more sources

Effects of Tocilizumab Therapy on Circulating B Cells and T Helper Cells in Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody, showed its therapeutic efficacy on neuromyelitis optica spectrum disorder (NMOSD).
Ye Liu, Huiming Zhang, Tian-Xiang Zhang, Meng Yuan, Chen Du, Pei Zeng, Zhenning Huang, Dongmei Jia, Guili Yang, Fu-Dong Shi, Fu-Dong Shi, Chao Zhang, Chao Zhang   +12 more
doaj   +1 more source