Results 101 to 110 of about 1,317,105 (347)

Retinal biomarkers of Alzheimer’s disease: insights from transgenic mouse models [PDF]

, 2017
In this paper, we use the retina as a window into the central nervous system and in particular to assess changes in the retinal tissue associated with the Alzheimer’s disease.
Ambrósio, António F., Bernardes, Rui, Chiquita, Samuel, Serranho, Pedro, Silva, Gilberto   +4 more
core   +1 more source

Central Nervous System Viral Diseases

, 2008
The nervous system has multiple intrinsic defenses against viral infection, including the blood–brain barrier. Yet, the postmitotic nature of neurons creates a uniquely vulnerable environment susceptible to irreversible damage. Various viruses can infect the different cell types within the central nervous system, neurons, oligodendrocytes, astrocytes ...
Johnson, R.T., Greenberg, B.M.
openaire   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Psychiatric Presentation of Creutzfeldt-Jakob Disease: A Case Study [PDF]

, 2011
Creutefeldt-Jakob disease is a fatal degenerative disorder of the central nervous system. The variability of its prodromal psychiatric and neurologic manifestation often obscures the diagnosis. This paper reports a case that illustrates the complexity of
Minninger, Kyra, Parsa, M.D., Mahmoud A.
core   +1 more source

Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. [PDF]

, 2015
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system.
Anderton, Ando, Andres, Apetoh, Astier, Awasthi, Bacchetta, Bacchetta, Barrat, Batten, Bennett, Borsellino, Brunkow, Cedeno-Laurent, Chen, Chen, Dalla Libera, Darrasse-Jeze, David, Dominguez-Villar, Durelli, El-Behi, Faria, Fitzgerald, Fitzgerald, Fitzgerald, Fletcher, Fontenot, Frisullo, Gagliani, Gandhi, Garin, Getts, Getts, Gregory, Groux, Haak, Haas, Haas, Harrington, Hilliard, Hong, Hori, Huan, Huang, Huber, Hunter, Iellem, Ilarregui, Jiang, Joller, Kipnis, Kohm, Komiyama, Kopcow, Korn, Korn, Korporal, Kroenke, Kuniyasu, Langrish, Laouar, Leech, Leonard, Li, Liblau, Lutterotti, Magnani, Mariathasan, Markiewicz, Martinez-Forero, Mascanfroni, McGeachy, Mehling, Miller, Mosmann, Muls, Noseworthy, O'Connor, Ohnmacht, Peng, Pflanz, Pflanz, Pitkanen, Pot, Pot, Pot, Rabinovich, Ramgolam, Ratts, Read, Rostami, Rovetto, Russell, Sakaguchi, Secor, Segal, Sela, Smith, Stephens, Stumhofer, Sundstedt, Takahashi, Takeda, Tigno-Aranjuez, Toscano, Turley, Tzartos, Uyttenhove, Veen, Venken, Venken, Vieira, Viglietta, Villarino, Voskuhl, Wang, Wang, Weiner, Wildbaum, Wildin, Xu, Yamaguchi, Yamazaki, Yang, Yang, Zhang, Zhang, Zhang, Zhang   +129 more
core   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Systemic and central nervous system metabolic alterations in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2019
Background Metabolic alterations, related to cerebral glucose metabolism, brain insulin resistance, and age-induced mitochondrial dysfunction, play an important role in Alzheimer’s disease (AD) on both the systemic and central nervous system level.
Vera van der Velpen, Tony Teav, Héctor Gallart-Ayala, Florence Mehl, Ioana Konz, Christopher Clark, Aikaterini Oikonomidi, Gwendoline Peyratout, Hugues Henry, Mauro Delorenzi, Julijana Ivanisevic, Julius Popp   +11 more
doaj   +1 more source

Clinical, imaging and histopathological features of isolated CNS lymphomatoid granulomatosis

Indian Journal of Radiology and Imaging, 2015
Lymphomatoid granulomatosis is a rare systemic angiocentric/angiodestructive, B cell lymphoproliferative disorder. Central nervous system involvement occurs as part of systemic disease.
Anil Kumar Patil, Mathew Alexander, Bijesh Nair, Geeta Chacko, Sunithi Mani, Sniya Sudhakar   +5 more
doaj   +1 more source

Severe panuveitis in neuro-Behçet’s disease in Malaysia: a case series [PDF]

, 2017
Behçet’s disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet’s.
Ahmad Tajudin, Liza Sharmini, Embong, Zunaina, John, Tharakan, Khairuddin, Othman, Mohtar, Ibrahim, Ryoji, Yanai   +5 more
core  

Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington’s disease [PDF]

, 2014
Huntington’s disease, the most common inherited neurodegenerative disease, is characterized by a dramatic loss of deep-layer cortical and striatal neurons, as well as morbidity in midlife.
Cowley, Glenn S., Heiman, Myriam, Kulicke, Ruth, Root, David E., Shema Tirosh, Reut, Stein, Rachael   +5 more
core   +1 more source