Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]
, 2009 Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams +37 more
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Differential in vitro infection of neural cells by astroviruses [PDF]
, 2019 Encephalitis remains a diagnostic conundrum in humans as over 50% of cases are managed without the identification of an etiology. Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this
Janowski, Andrew B +2 more
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Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging [PDF]
, 2017 Central nervous system graft-versus-host disease can present quite a diagnostic challenge. We herein present a case of histologically-confirmed chronic graft versus host disease (GVHD) involving the central nervous system that occurred at 19 months after
Chiba Shigeru +13 more
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The differential diagnosis of chorea [PDF]
, 2007 Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the ...
Tabrizi, SJ, Wild, EJ
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Frontiers in Cellular Neuroscience, 2020 Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition characterized by a significant accumulation of lipids in the liver without excessive alcohol consumption.
Xiuping Li +12 more
doaj +1 more source
The Central Nervous System Involvement in Fabry Disease
Journal of Inborn Errors of Metabolism and Screening, 2016 Fabry disease (FD) is an X-linked, lysosomal storage disorder caused by a mutation in the alpha galactosidase (GLA) gene leading to a deficiency in α-galactosidase A enzyme (α-Gal A) activity, which in turn results in accumulation of glycosphingolipids ...
Alessandro Burlina MD, PhD +1 more
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Review of Rabies Preventions and Control [PDF]
, 2017 Rabies is an acute viral infection of the central nervous system, caused by a lyssavirus in the family Rhabdoviridae. It is zoonotic viral disease that can affect all mammals, including humans, cats, dogs, and wildlife and farm animals.
Abdela, N. (Nejash) +1 more
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Diagnostic value of exosomal miR-1246 for Parkinson’s disease [PDF]
Xin yixueObjective To investigate the diagnostic value of exosomal miR-1246 for Parkinson’s disease （PD）. Methods Serum samples were collected from 30 PD patients （PD group） and 30 healthy controls （control group） receiving physical examination in the Second ...
WANG Xiaobei, YANG Shan, LI Yatan, YANG Xinling
doaj +1 more source
Design and construction of a distributed sensor NET for biotelemetric monitoring of brain energetic metabolism using microsensors and biosensors [PDF]
, 2010 Neurochemical pathways involved in brain physiology or disease pathogenesis are mostly unknown either in physiological conditions or in neurodegenerative diseases.
Bazzu, Gianfranco +5 more
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Role of Thrombin in Central Nervous System Injury and Disease
Biomolecules, 2021 Thrombin is a Na+-activated allosteric serine protease of the chymotrypsin family involved in coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin in the brain has been explored. Low concentrations of thrombin are
Nathan A. Shlobin +4 more
doaj +1 more source