Chain-Modified Pyridino-N Substituted Nicotine Compounds for Use in the Treatment of CNS Pathologies [PDF]
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, addiction to opiates, addiction to alcohol, addiction to tobacco products, addiction to nicotine, schizophrenia and related diseases, depression and related ...
Ayers, Joshua T.+3 more
core +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier+8 more
wiley +1 more source
CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder
Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoantibody-triggered central nervous system (CNS) demyelinating disease that primarily affects the spinal cord, optic nerves and brainstem.
Wenjun Zhang+12 more
doaj +1 more source
A reaction-diffusion model for the progression of Parkinson's disease [PDF]
The temporal and spatial development of Parkinson's disease has been characterised as the progressive formation of {\alpha}-synuclein aggregations through susceptible neuronal pathways. This article describes a new model for this progression mechanism in which Parkinsonian damage moves over time through the nervous system by the combined effect of the ...
arxiv
ON CERTAIN CASES OF DISEASE OF THE CENTRAL NERVOUS SYSTEM IN WHICH NO NAKED-EYE CHANGES ARE FOUND AT THE POST-MORTEM EXAMINATION. [PDF]
SeymourJ. Sharkey
openalex +1 more source
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi+6 more
wiley +1 more source
A CASE OF IDIOCY WITH UNIVERSAL RIGIDITY, THE RESULT OF SYPHILITIC DISEASE OF THE CENTRAL NERVOUS SYSTEM [PDF]
Angel Money
openalex +1 more source
Inflammation and central nervous system Lyme disease
Lyme disease, caused by the bacterium Borrelia burgdorferi, can cause multi-systemic signs and symptoms, including peripheral and central nervous system disease. This review examines the evidence for and mechanisms of inflammation in neurologic Lyme disease, with a specific focus on the central nervous system, drawing upon human studies and controlled ...
Brian A. Fallon+3 more
openaire +4 more sources
Correspondence of MRI and nTMS With EDSS in Multiple Sclerosis: Longitudinal Follow‐Up Study
ABSTRACT Objectives Considering the characteristics of multiple sclerosis (MS) disease and its impact on motor disability, this study aims to assess the functional integrity of the corticospinal tract by examining motor evoked potentials (MEPs), Expanded Disability Status Scale (EDSS) scores, magnetic resonance imaging (MRI) lesion counts, and ...
Antonia Bralić+13 more
wiley +1 more source
Virtual Nervous Systems for Self-Assembling Robots - A preliminary report [PDF]
We define the nervous system of a robot as the processing unit responsible for controlling the robot body, together with the links between the processing unit and the sensorimotor hardware of the robot - i.e., the equivalent of the central nervous system in biological organisms.
arxiv