Results 171 to 180 of about 25,848,997 (286)

The use of <i>Drosophila</i> to study sleep impairments in stimulant use disorder. [PDF]

Front Cell Dev Biol
Miles M, Karatas M, Rothenfluh A.
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Low‐Intensity Focused Ultrasound Enables Temporal Modulation of Human Midbrain Organoid Differentiation

Advanced Science, EarlyView.
In this study, we demonstrate that low‐intensity ultrasound stimulation enables temporal modulation of midbrain organoid differentiation using a modular multi‐well stimulation platform. In particular, we show that ultrasound promotes the proliferation of dopaminergic progenitor cells.
Jinseong Jeong, Yehhyun Jo, Youngsun Lee, Eunyoung Jang, Yeonji Jeong, Won Do Heo, Jennifer H. Shin, Mi‐Ok Lee, Hyunjoo J. Lee   +8 more
wiley   +1 more source

Validation of the Stimulant Use Motives Scale and Assessment of Its Associations with Psychosocial Functioning and Sexual Health in U.S. Men Who Have Sex with Men. [PDF]

Subst Use Misuse
Esquivel-Mendoza JA, Weinstein ER, Porras A, Pantalone DW, Biello KB, Mayer K, Mimiaga MJ, Safren SA.   +7 more
europepmc   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Examining Increased Ritalin and Adderall Use Among Low-Income People Who Use Drugs: Mixed Methods Study. [PDF]

JMIR Form Res
Aronson ID, Quiles R, Cramer A, Fong C, Bennett AS.   +4 more
europepmc   +1 more source

An Efficient Biological Codon Recognition Reservoir Computing System Based on Low‐Energy Epitaxial Hf0.52Zr0.48O2 Ferroelectric Memristors

Advanced Science, EarlyView.
This work reports on epitaxially grown Hf0.52Zr0.48O2 ferroelectric memristors with high stability (high durability exceeding 108 cycles and a retention time exceeding 104 s for 16 states) and ultra‐low operating energy consumption (∼121 fJ). A memristor array‐based reservoir computing system is constructed and applied for the first time in the field ...
Ying Liu, Jikang Xu, Yongqing Jia, Wenxuan Wang, Weifeng Zhang, Biao Yang, Xiaobing Yan   +6 more
wiley   +1 more source

The role of histamine in narcolepsy type 1: a narrative review. [PDF]

Front Neurol
Liang W, Yan X, Zhao Y, Zhang D, Fu Y, Sui G, Zhang W.   +6 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Diseases of the nervous system /

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and ...
Sontheimer, Harald,author.
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