Results 41 to 50 of about 44,555 (311)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Fast Times in Federal Court and the Need for Flexibility [PDF]
, 2018 The shifting landscape of criminal prosecutions involving designer drugs presents several novel legal issues. There are different ways to address these issues when they are the result of the production, possession, or distribution of as-of-yet ...
Moore, K. Michael
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Diagnosis and management of central hypersomnias
Therapeutic Advances in Neurological Disorders, 2012 Central hypersomnias are diseases manifested in excessive daytime sleepiness (EDS) not caused by disturbed nocturnal sleep or misaligned circadian rhythms.
Karel Sonka, Marek Susta
doaj +1 more source
Repetitive stimulation in the central nervous system [PDF]
Spinal Cord, 1983 There has been a considerable change in ideas about the effect of a lesion in the central nervous system (CNS) and the view of a fixed neurological deficit following a lesion in the CNS is no longer tenable. The clinical picture seen after a partial lesion in the CNS depends in part on the destruction or partial destruction of nerve pathways and cells,
openaire +2 more sources
Does stimulant therapy help adult ADHD? [PDF]
, 2003 Central nervous system stimulants improve symptoms of attention deficit-hyperactivity disorder (ADHD) in adults (strength of recommendation: B, based on an older, inconclusive systematic review, a lesser-quality systematic review, and several newer small
Leach, Laura, Lutton, Michelle E.
core
Managing constipation in adults with co-morbidities [PDF]
, 2016 Constipation can be described in a number of ways but in general it is related to straining, reduced frequency of defecation and/or a sensation of incomplete bowel emptying.
Gardiner, Anji, Hilton, Andrea
core +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The study of Medicinal Compounds That Stimulate the Central Nervous System [PDF]
BeyhaghIntroduction: The brain is a complex system that consumes a significant amount of energy and oxygen, and its chemical reactions are responsible for actions and behaviors. The nervous system consists of billions of specialized cells that transmit messages
Roohallah Yousefi
doaj