Results 61 to 70 of about 22,295,129 (298)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Notch-mediated re-specification of neuronal identity during central nervous system development [PDF]
, 2021 Neuronal identity has long been thought of as immutable, so that once a cell acquires a specific fate, it is maintained for life.(1) Studies using the overexpression of potent transcription factors to experimentally reprogram neuronal fate in the mouse ...
Suzuki, Sachihiro C. +7 more
core +1 more source
Central nervous system stimulating activity of phytexponent preparation [PDF]
, 2021 Disorders affecting the central nervous system are categorized as some of the chronic conditions that affect mankind. These have been managed by prescription of the central nervous stimulants that help in reducing the symptoms such as fatigue and as well
Namatore, Sharon Wabwile
core +1 more source
Advances and Considerations in Attention-Deficit/Hyperactivity Disorder Pharmacotherapy [PDF]
Acta Medica Iranica, 2011 Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric disorder associated with significant impairments in occu¬pational, academic, neuropsychological, and social functioning.
Mohammad Mohammadi, Shahin Akhondzadeh
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Experimental Models of SARS-COV-2 Infection in the Central Nervous System
, 2022 Coronavirus disease 2019 (COVID-19) has raised serious concerns worldwide due to its great impact on human health and forced scientists racing to find effective therapies to control the infection and a vaccine for the virus. To this end, intense research
Anna Maria Paoletti +8 more
core +1 more source
Diabetes and substance use: a perspective within drug rehabilitation
Exploration of Medicine, 2023 Diabetes mellitus has become increasingly more common and diagnosed within the global population. Coupled with the continued prevalence of substance use, there are some distinct considerations for users suffering (knowingly or unknowingly) from type 1 or
Abuelgasim Elrasheed A. Alhassan +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Whole-central nervous system functional imaging in larval Drosophila [PDF]
, 2015 This work was supported by the Howard Hughes Medical Institute.Understanding how the brain works in tight concert with the rest of the central nervous system (CNS) hinges upon knowledge of coordinated activity patterns across the whole CNS.
Pulver, Stefan +6 more
core +1 more source