Results 71 to 80 of about 22,295,129 (298)

Prevalence of and factors associated with the use of methylphenidate for cognitive enhancement among university students

Einstein (São Paulo), 2019
Objective To estimate the prevalence of and factors associated with the use of methylphenidate for cognitive enhancement among undergraduate students.
Raissa Carolina Fonseca Cândido, Edson Perini, Cristiane Menezes de Pádua, Daniela Rezende Junqueira   +3 more
doaj   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The NOD (Naltrexone for Overdose Prevention) study protocol: a pilot randomized controlled trial of intramuscular naltrexone for opioid overdose prevention among people who use stimulants living with or at risk for HIV

Addiction Science & Clinical Practice
Background Drug-related mortality in the United States continues to transform, marked by a surge in overdose deaths involving both fentanyl and stimulants.
Ayesha Appa, Xochitl Luna Marti, Stefan Baral, Steven Shoptaw, Alexander R. Bazazi, Matthew A. Spinelli, Dave Glidden, Monica Gandhi, Phillip Coffin   +8 more
doaj   +1 more source

Retrospective Review of Trend in Modafinil Overexposures Reported to American Poison Information Centers [PDF]

Asia Pacific Journal of Medical Toxicology, 2014
Background:Modafinil, a non-amphetamine central nervous system stimulant, is a wakefulness-promoting agent indicated for use in shift work sleep disorder, narcolepsy, and obstructive sleep apnea. The trend in modafinil overexposure over a ten-year period
Kristin Bohnenberger, Edward Krenzelok
doaj  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Blood pressure, heart rate and CNS stimulant medication use in children with and without ADHD: analysis of NHANES data

Frontiers in Pediatrics, 2014
It is estimated that 2-3% of children in the US have hypertension (HTN) and 8% of children ages 4-17 carry the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD).
Susan M Hailpern, Brent M Egan, Kimberly D Lewis, Carol eWagner, Ghassan F Shattat, Doaa I Al Qaoud, Ibrahim F. Shatat   +6 more
doaj   +1 more source

Metoprolol treatment of dual cocaine and bupropion cardiovascular and central nervous system toxicity [PDF]

Clinical and Experimental Emergency Medicine, 2019
Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from cocaine or bupropion use.
John R. Richards, Jessica B. Gould, Erik G. Laurin, Timothy E. Albertson   +3 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source