Results 91 to 100 of about 141,503 (294)

Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord

open access: yesFrontiers in Cellular Neuroscience, 2019
Propriospinal interneurons (INs) communicate information over short and long distances within the spinal cord. They act to coordinate different parts of the body by linking motor circuits that control muscles across the forelimbs, trunk, and hindlimbs ...
Alex M. Laliberte   +3 more
doaj   +1 more source

GENESIS: A System for Simulating Neural Networks [PDF]

open access: yes, 1988
We have developed a graphically oriented, general purpose simulation system to facilitate the modeling of neural networks. The simulator is implemented under UNIX and X-windows and is designed to support simulations at many levels of detail ...
Bhalla, Upinder S.   +3 more
core  

Management and Control of Domestic Smart Grid Technology [PDF]

open access: yes, 2010
Emerging new technologies like distributed generation, distributed storage, and demand-side load management will change the way we consume and produce energy.
Bakker, Vincent   +4 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

On the Kinematic Motion Primitives (kMPs) - Theory and Application

open access: yesFrontiers in Neurorobotics, 2012
Human neuromotor capabilities guarantee a wide variety of motions. A full understanding of human motion can be beneficial for rehabilitation or performance enhancement purposes, or for its reproduction on artificial systems like robots. This work aims at
Federico Lorenzo Moro   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

The Kazhdan-Lusztig conjecture for finite W-algebras

open access: yes, 1992
We study the representation theory of finite W-algebras. After introducing parabolic subalgebras to describe the structure of W-algebras, we define the Verma modules and give a conjecture for the Kac determinant.
B. L. Feigin   +16 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A Core Circuit Module for Cost/Benefit Decision

open access: yesFrontiers in Neuroscience, 2012
A simple circuit for cost-benefit decision derived from behavioral and neural studies of the predatory sea-slug Pleurobranchaea may closely resemble that upon which the more complex valuation and decision processes of the social vertebrates are built ...
Keiko eHirayama   +3 more
doaj   +1 more source

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