Results 191 to 200 of about 15,038 (251)

A time-coupled multi-objective distributionally robust chance-constrained framework for grid resilience enhancement using mobile emergency generators. [PDF]

Sci Rep
Ashokaraju D, Ramamoorthy ML, Simon D, Ashok N, Bhowmik A.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Speed-dependent turning strategies in quadrupedal locomotion: insights from computational modeling. [PDF]

Front Bioeng Biotechnol
Molkov YI, Mohammed MAY, Stell T, Harralson A, Jeter R, Rybak IA.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Odor-induced sweetness enhancement: EEG evidence for olfactory and gustatory cross-modal interactions. [PDF]

Curr Res Food Sci
Yang Y, Guo Y, Hua Z, Wang Q, Shi Y, Men H.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Not All Spikes Are Equal. [PDF]

J Clin Med
Datta AN.
europepmc   +1 more source

Letter to the Editor: Clarifying the Scientific Basis and Clinical Relevance of DMI Therapy. [PDF]

Pediatr Phys Ther
Kreindler J, Weltman JA.
europepmc   +1 more source

Adaptive reinforcement learning framework for sustainable microgrid optimization in arid urban environments. [PDF]

Sci Rep
Mohamed MAS, Almazam K, Alzahrani M, Majrashi AA, Garo OO, Lagebo ML.   +5 more
europepmc   +1 more source

Spectral dependence as a framework for neural coordination. [PDF]

Curr Res Neurobiol
Besosa C, Qin Y, Burke SN, Maurer AP.
europepmc   +1 more source