Results 61 to 70 of about 141,503 (294)

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source

The effect of octopamine on the locust stomatogastric nervous system

Frontiers in Physiology, 2012
Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory
David eRand, Daniel eKnebel, Daniel eKnebel, Amir eAyali, Amir eAyali   +4 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Modeling Small Oscillating Biological Networks in Analog VLSI [PDF]

, 1989
We have used analog VLSI technology to model a class of small oscillating biological neural circuits known as central pattern generators (CPG). These circuits generate rhythmic patterns of activity which drive locomotor behaviour in the animal.
Bower, James M., Mead, Carver, Ryckebusch, Sylvie   +2 more
core  

Silicon central pattern generators for cardiac diseases [PDF]

The Journal of Physiology, 2015
AbstractCardiac rhythm management devices provide therapies for both arrhythmias and resynchronisation but not heart failure, which affects millions of patients worldwide. This paper reviews recent advances in biophysics and mathematical engineering that provide a novel technological platform for addressing heart disease and enabling beat‐to‐beat ...
Nogaret, Alain, O'Callaghan, Erin L, Lataro, Renata M, Salgado, Helio C, Meliza, C Daniel, Duncan, Edward, Abarbanel, Henry D I, Paton, Julian F R   +7 more
openaire   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Phase-specific premotor inhibition modulates leech rhythmic motor output

eLife
Understanding how motoneuron activity is finely tuned remains an open question. Leeches are a highly suitable organism for studying motor control due to their well-characterized behaviors and relatively simple nervous system.
Martina Radice, Agustin Sanchez Merlinsky, Federico Yulita, Lidia Szczupak   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

1/4 Partial Breaking of Global Supersymmetry and New Superparticle Actions [PDF]

, 1999
We construct the worldline superfield massive superparticle actions which preserve 1/4 portion of the underlying higher-dimensional supersymmetry. The rest of supersymmetry is spontaneously broken and realized by nonlinear transformations.
Achucarro, Adawi, Bagger, Bagger, Bagger, Bandos, Bandos, Bellucci, Berkooz, Callan, Coleman, de Azcárraga, de Azcárraga, E. Ivanov, F. Delduc, Ferrara, Gauntlett, Gauntlett, Gauntlett, Gauntlett, Gonzalez-Rey, Hughes, Hughes, Ivanov, Ivanov, Ivanov, Ivanov, Ogievetsky, Ohta, Roček, S. Krivonos, Townsend, Tseytlin, Volkov, Volkov, Witten   +35 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source