Childhood obesity and central precocious puberty
Frontiers in Endocrinology, 2022 Childhood obesity is a major public health problem worldwide, and the relationship between obesity and central precocious puberty has long been confirmed, however, the mechanisms underlying this association remain elusive. This review provides an overview of the recent progress regarding how childhood obesity impacts on hypothalamic-pituitary-gonadal ...
Li Shi, Zhiyan Jiang, Li Zhang
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Central precocious puberty: From genetics to treatment [PDF]
Best Practice & Research Clinical Endocrinology & Metabolism, 2018 Central precocious puberty (CPP) results from early activation of the hypothalamic - pituitary -gonadal (HPG) axis and follows the same sequence as normal puberty. While many factors involved in pubertal initiation remain poorly understood, the kisspeptin system is known to play a key role. Currently, mutations in the kisspeptin system, MKRN3, and DLK1
Schneider Aguirre, Rebecca +1 more
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Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty [PDF]
Yearbook of Paediatric Endocrinology, 2020 Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked to higher disease burden later in life. The mechanisms underlying this association remain elusive. Here we show that brain ceramides participate in the control of female puberty and contribute to its alteration in early-onset obesity in rats.
Violeta Heras +19 more
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Van Maldergem syndrome-1 in a patient with central precocious puberty: A case report. [PDF]
Medicine (Baltimore)Wang Y +6 more
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Early-life obesity as a risk factor for central precocious puberty - A commentary on "Incidence of central precocious puberty and the role of body mass index in Korea". [PDF]
Ann Pediatr Endocrinol MetabLee HS.
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Idiopathic Central Precocious Puberty and Attention Deficit Hyperactivity Disorder: A Clinical Case Study [PDF]
Eur PsychiatryJuárez G.
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Transient central precocious puberty: a new entity among the spectrum of precocious puberty? [PDF]
Italian Journal of Pediatrics, 2021 Abstract Objective Recently, we observed some cases of Precocious Puberty (PP) with a partial central activation of hypothalamic-pituitary-gonadal (HPG) axis that tended to normalized in 6–12 months. To evaluate the frequency of this form within the spectrum of forms of PP, we retrospectively assessed the clinical ...
Assirelli V +6 more
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Aвтоимун тироидит по долга употреба на агонист на гонадотропин- ослободувачки хормон како третман за предвремен централен пубертет – приказ на случај [PDF]
, 2020 There is a small number of studies that have reported abnormalities in endocrine function after a long-term gonadotropin-releasing hormone agonist (GnRHa) treatment in girls. This treatment is considered as safe and effective by most authors.
Krstevska-Konstantinova, Marina +3 more
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Central precocious puberty in a 3 year-old girl with Phenylketonuria: a rare association? [PDF]
, 2014 Background Central precocious puberty (CPP) and phenylketonuria (PKU) are two rare conditions, the latter being the rarer. To date, only one case featuring both these conditions has been reported, and hyperphenylalaninemia was assumed triggering CPP.
Donaldson, Malcolm +3 more
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Pediatric Drugs, 2004 Central precocious puberty (CPP) is characterized by early pubertal changes, acceleration of growth velocity, and rapid bone maturation that often result in reduced adult height. An onset of pubertal signs before the age of 8 years in girls and 9 years in boys should always be evaluated.
ANTONIAZZI, Franco, ZAMBONI, Giorgio
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