Results 241 to 250 of about 6,129,726 (293)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Astrocyte-specific NRCAM deficiency promotes GABAergic synapse pruning to drive central sensitization in bone cancer pain. [PDF]

J Transl Med
Zhang Z, Hou Y, Mao Y, Jiang L, Lu C, Yu J, Huang Y, Xu R, Huang S, Zhang X, Zhu H, Zhang W, Sun Y, Ma Z.   +13 more
europepmc   +1 more source

Central sensitization, work-related stress, and musculoskeletal pain symptoms in desk-based workers with and without migraine: a cross-sectional study. [PDF]

J Headache Pain
Onan D, Yeşildaş PY, Akgör MC, Porsnok D.   +3 more
europepmc   +1 more source

Central sensitization in patients with chronic pelvic pain resistant to hormonal therapy: A cross-sectional study of prevalence and clinical correlates in a tertiary referral cohort. [PDF]

Acta Obstet Gynecol Scand
Alawadi H, Cid M, Delotte J, Gauci PA.
europepmc   +1 more source

Interictal thermal pain hypersensitivity and central sensitization in migraine patients: a case-control study using quantitative sensory testing. [PDF]

Head Face Med
Suzuki K, Suzuki S, Haruyama Y, Shioda M, Kobayashi S, Hida R, Hirata K.   +6 more
europepmc   +1 more source

The Relationship Between Physical Activity and Pain, Pain-Related Cognitions, and Central Sensitization in Patients With Midportion Achilles Tendinopathy. [PDF]

Orthop J Sports Med
Van Bogaert W, Potter MN, Smith AK, Smitheman HP, Matusinec ZJ, Grävare Silbernagel K.   +5 more
europepmc   +1 more source

Clinical phenotypes of neuropathic pain and central sensitization in patients with knee osteoarthritis: demographic data, radiographic severity, and pain intensity. [PDF]

BMC Musculoskelet Disord
Kubo M, Nosaka Y, Kumagai K, Amano Y, Isoya E, Imai S.   +5 more
europepmc   +1 more source

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Central sensitization inventory in endometriosis

Pain, 2021
Abstract A key clinical problem is identifying the patient with endometriosis whose pain is complicated by central nervous system sensitization, where conventional gynecologic treatment (eg, hormonal therapy or surgery) may not completely alleviate the pain.
Natasha L, Orr, Kate J, Wahl, Michelle, Lisonek, Angela, Joannou, Heather, Noga, Arianne, Albert, Mohamed A, Bedaiwy, Christina, Williams, Catherine, Allaire, Paul J, Yong   +9 more
openaire   +2 more sources

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

Journal of Pain, 2019
Central sensitization is considered to have a pathophysiological role in chronic low back pain (LBP). Whether individuals with increased central sensitization early in their condition are more likely to develop persistent pain or whether it increases ...
Michele Sterling, Paul Hodges
exaly   +2 more sources

Central Sensitization and Pain: Pathophysiologic and Clinical Insights

Current Neuropharmacology
Central sensitization is an increased responsiveness of nociceptive neurons in the central nervous system to their normal or subthreshold afferent input.
Michele Curatolo
exaly   +2 more sources