Results 251 to 260 of about 6,129,726 (293)

Multiple chemical sensitivity: On the scent of central sensitization

International Journal of Hygiene and Environmental Health, 2013
Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by recurrent, non-specific symptoms in response to chemically unrelated exposures in non-toxic concentrations. Although the pathophysiology of MCS remains unknown, central sensitization may be an important factor contributing to the clinical manifestations.To use quantitative ...
Tran, Marie Thi Dao, Arendt-Nielsen, Lars, Kupers, Ron, Elberling, Jesper   +3 more
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The Pharmacology of Central Sensitization

Journal of Musculoskeletal Pain, 2002
SUMMARYObjective: The purpose of this review is to show how central mechanisms of pain transmission relate to pharmacological systems that are responsible for the generation of central sensitization states.Findings: Pain transmission is a complex process involving the interplay between excitatory and inhibitory systems acting at different levels of the
Rie Suzuki, Anthony H. Dickenson
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Evidence for central sensitization as classified by the central sensitization inventory in patients with pain and hypermobility

Pain Practice
AbstractIntroductionPain is a very common complaint among patients with hypermobile Ehlers‐Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSDs). Often challenging to treat, insights into the underpinnings of pain in this population have been fleeting.
Mehul J. Desai, Mason Brestle, Holly Jonely   +2 more
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Sensitivity of the blue-sensitive cones across the central retina

Vision Research, 1982
We measured increment thresholds up to 5 degrees eccentricity using a 10' dia flash viewed against 10(4) td of 572-nm background. We found two distinct sensitivity profiles, one with flash wavelengths 410-470 nm and another with 520-580 nm. Spectral sensitivity plots indicate blue-sensitive cones and green-sensitive cones for the two profiles ...
J A, Castańo, H G, Sperling
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Central insulin enhances sensitivity to cholecystokinin

Physiology & Behavior, 1995
Insulin acts in the brain to reduce food intake and body weight. Cholecystokinin (CCK) reduces meal size when administered peripherally. The purpose of these experiments was to examine their interaction. In Experiment 1, Long-Evans rats were infused with vehicle or insulin at doses from 0.5 to 2.0 mU/day into the third cerebral ventricles. Doses of 1.0
C A, Riedy, M, Chavez, D P, Figlewicz, S C, Woods   +3 more
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The Role of Peptides in Central Sensitization

2009
Peptides released in the spinal cord from the central terminals of nociceptors contribute to the persistent hyperalgesia that defines the clinical experience of chronic pain. Using substance P (SP) and calcitonin gene-related peptide (CGRP) as examples, this review addresses the multiple mechanisms through which peptidergic neurotransmission ...
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Central Sensitization in Humans: Assessment and Pharmacology

2015
It is evident that chronic pain can modify the excitability of central nervous system which imposes a specific challenge for the management and for the development of new analgesics. The central manifestations can be difficult to quantify using standard clinical examination procedures, but quantitative sensory testing (QST) may help to quantify the ...
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Central Sensitization

The Clinical Journal of Pain, 2016
John, Srbely, Brian, Vadasz, Jay, Shah, Naomi Lynn, Gerber, Siddhartha, Sikdar, Dinesh, Kumbhare   +5 more
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The Neurobiology of Central Sensitization

Journal of Musculoskeletal Pain, 2002
SUMMARYObjectives: This review discusses plasticity of excitatory synaptic transmission in the spinal dorsal horn and the role of this plasticity in contributing to the pathogenesis of pain hypersensitivity.Findings: In the dorsal horn pain transmission is mediated primarily through excitatory glutamatergic synapses.
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Fibromyalgia: The Prototypical Central Sensitivity Syndrome

Current Rheumatology Reviews, 2015
Fibromyalgia syndrome (FM), the most common central sensitivity syndrome (CSS) affecting over 5% of the population, is a disorder of chronic widespread pain accompanied by numerous other symptoms that causes significant functional impairment. The core FM symptom domains can be recalled using the FIBRO mnemonic and include Fatigue and Fog (cognitive ...
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