Results 71 to 80 of about 34,314 (205)

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Mixed venous versus central venous oxygen saturation in patients undergoing on pump beating coronary artery bypass grafting

Saudi Journal of Anaesthesia, 2010
Objective: To examine the validity of central venous oxygen saturation (ScvO 2 ) as a numerical substitution of mixed venous oxygen saturation (SvO 2 ) in adult patients undergoing normothermic on pump beating coronary artery bypass grafting (CABG ...
Alshaer Ahmad, Abdel-Meguid Mohamed, Ibraheim Osama, Fawzi Khaled, AbdulSalam Ibrahim, Sheta Saad, Abdullah Khaled, El-Demerdash Ahmed, Al-Satli Raed, AbdelAll Mohamed, Bakir Bakir, AlNahal Nezar, Abdulrahman Yasser, AlHamoud Hanaa   +13 more
doaj  

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Correlation Between ScVO2, PCO2 Gap (Artery-Vein PCO2 Gradient) and Respiratory Quotient with Cardiac Output in Septic Shock Patients

JAI (Jurnal Anestesiologi Indonesia)
Background: Septic shock is a life-threatening condition characterized by cardiovascular dysfunction, which can cause multi-organ failure and high mortality rates. Central venous oxygen saturation (ScVO2), PCO2 Gap, and respiratory quotient are potential
Eliezer Iswara Anindita, Pradana Bayu Rakhmatjati, Dina Paramita, Taufan Pramadika   +3 more
doaj   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Rare complication of internal jugular vein catheter ectopically placed into the dural sinus: a case report

Frontiers in Pediatrics
BackgroundCentral venous catheterization is a procedure involving the percutaneous insertion of a catheter into a central vein, such as the internal jugular, subclavian, or femoral vein. It is frequently used for monitoring central venous pressure (CVP),
Lu Wang, Yan Jiang
doaj   +1 more source

Central Venous-to-Arterial CO2 Gap Is a Useful Parameter in Monitoring Hypovolemia-Caused Altered Oxygen Balance: Animal Study

Critical Care Research and Practice, 2013
Monitoring hypovolemia is an everyday challenge in critical care, with no consensus on the best indicator or what is the clinically relevant level of hypovolemia.
Szilvia Kocsi, Gabor Demeter, Daniel Erces, Eniko Nagy, Jozsef Kaszaki, Zsolt Molnar   +5 more
doaj   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source