Results 91 to 100 of about 4,466,602 (311)
Sustained effects of acupuncture stimulation investigated with centrality mapping analysis
Frontiers in Human Neuroscience, 2016 Acupuncture can have instant and sustained effects, however its mechanisms of action are still unclear. Here we investigated the sustained effect of acupuncture by evaluating centrality changes in resting-state functional magnetic resonance imaging after
Xiangyu Long +13 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Hypergraph Representations: A Study of Carib Attacks on Colonial Forces, 1509-1700
Journal of Historical Network Research, 2017 Network data consisting of recorded historical events can be represented as hyper-graphs where the ties or events can connect any number of nodes or event related attributes.
Termeh Shafie +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2020 During the past decades, central banks acquired considerable independence from democratic institutions under the Central Bank Independence (CBI) template. Yet, the changing role of central banks since the 2007–2008 crisis has led to a (re)politicization of central banking and has weakened the scientific and political consensus on the CBI model. In turn,
Fontan, Clément, Larue, Louis
openaire +3 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
To centralize or not to centralize?
, 2011 The CEO's dilemma-were the gains of centralization worth the pain it could cause?-is a perennial one. Business leaders dating back at least to Alfred Sloan, who laid out GM's influential philosophy of decentralization in a series of memos during the 1920s, have recognized that badly judged centralization can stifle initiative, constrain the ability to ...
Campbell, Andrew +2 more
openaire +2 more sources
Matrix: Jurnal Manajemen Teknologi dan InformatikaSocial media has a vital role in general elections in Indonesia because social media is one of the platforms used by presidential candidates for campaigns to gain public support. General elections in Indonesia occur every five years.
Neny Sulistianingsih +1 more
doaj +1 more source