Results 111 to 120 of about 169,804 (304)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Co-authorship network analysis of Iranian medical science researchers: A social network analysis

مجله علم‌سنجی کاسپین, 2015
Background and aim: Co-authorship networks of scientists exhibit a pattern of developing and complicated networks. The aim of the present study was to analyze the power structure in co-authorship networks of Iranian medical science researchers based on ...
Faramarz Sohieli, Mozafar Cheshme Sohrabi, Samira Atashpaykar   +2 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

econet: Estimation of Parameter-Dependent Network Centrality Measures

, 2018
Provides methods for estimating parameter-dependent network centrality measures with linear-in-means models. Both non linear least squares and maximum likelihood estimators are implemented.
Valerio Leone Sciabolazza, Sida Peng, Marco Battaglini, Eleonora Patacchini   +3 more
core  

Centrality measures for immunization of weighted networks [PDF]

, 2016
Effective immunization of individual communities with minimal cost in vaccination has made great discussion surrounding the realm of complex networks.
Mohammad Khansari, Amin Kaveh, Zainabolhoda Heshmati, et al.   +2 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Komparasi sentralitas pusat kegiatan pada kota dan kabupaten di Provinsi Kalimantan Barat

Region: Jurnal Pembangunan Wilayah dan Perencanaan Partisipatif
Wilayah merupakan jaringan perkotaan dan setiap kota dalam wilayah saling berhubungan. Struktur keruangan wilayah dibentuk oleh jaringan yang menghubungkan titik pusat aktivitas dengan saluran penghubung berupa garis infrastruktur.
Syaiful Muazir, Lestari Lestari, Muhammad Nurhamsyah, Muhammad Ridha Alhamdani   +3 more
doaj   +1 more source

New centrality measure: ksi-centrality

CoRR
We introduce new centrality measures, called ksi-centrality and normalized ksi-centrality measure the importance of a node up to the importance of its neighbors. First, we show that normalized ksi-centrality can be rewritten in terms of the Laplacian matrix such that its expression is similar to the local clustering coefficient. After that we introduce
openaire   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source