Results 31 to 40 of about 81,839 (258)

The Centre-Periphery Dialectics in Eastern Sicily Retail System. An Exploratory Research

open access: yesBollettino della Società Geografica Italiana, 2021
This paper aims at scrutinizing from an historical perspective the deep transformations shaped by retail spaces and new consumption patterns challenging long-entrenched dichotomies, such as the centre-periphery one.
Caterina Barilaro   +3 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi   +9 more
wiley   +1 more source

On the future of music history in professional and central-peripheral European musical circumstances [PDF]

open access: yesMuzikologija, 2019
In considering the chosen topic, I proceed from the complex relationship between music history, music historiography and musicology, focusing on musicology as an interdisciplinary branch of music history.
Veselinović-Hofman Mirjana
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Centre–Periphery Antagonism in Adjudication: A Case Study on the Spatial Dimension of the Political

open access: yesActa Universitatis Lodziensis Folia Iuridica, 2021
One of the key elements of the critical theory of adjudication is the identification of an objective antagonism that is at stake behind a given court case.
Rafał Mańko
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Echoes of Evil: Haunted Houses and Lingering Terrors in "The Amityville Horror" and "The Conjuring"

open access: yesZagadnienia Rodzajów Literackich
Bruce F. Kawin defines horror by its recurring motifs and its primary goal: to frighten and unsettle the audience (4). Beyond its entertainment value, horror functions within a dynamic semiotic space, where spatial structures encode tensions between ...
Julia Seltnerajch
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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