Results 121 to 130 of about 4,708,577 (333)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Transcatheter mitral valve-in-valve implantation in patients with degenerated bio-prostheses – Experience of a Centre in Mexico

open access: diamond, 2017
José A. Merino-Rajme   +7 more
openalex   +1 more source

Non-muscle myosin II takes centre stage in cell adhesion and migration

open access: yesNature reviews. Molecular cell biology, 2009
M. Vicente-Manzanares   +3 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Livsvärldar och globalisering i Lukas Moodyssons "Mammut"

open access: yesTidsskrift for Kulturforskning
In 2009, Lukas Moodysson’s motion picture Mammoth had its opening. The movie is set in three different locations – New York, Thailand, and the Philippines – and follows several characters and their individual life stories. In Swedish and Anglo-Saxon news
Magnus Rodell
doaj  

Grandeurs et déclin du centre d’interprétation

open access: yesTéoros, 2005
Les centres d’interprétation semblent avoir la cote ces jours-ci. Bien avant que des centres d’interprétation, comme celui qui aurait pu pérenniser la bataille du Long-Sault, permettent de rappeler aux sens ce qu’il n’était plus possible de voir, l ...
Luc Noppen, Lucie K. Morisset
doaj  

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