Results 141 to 150 of about 12,577,314 (296)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

World Agroforestry Centre Financial Statement and Auditor's Report for 2009

, 2010
World Agroforestry Centre Financial Statement and Auditor's Report for the year ended 31 December 2009 as prepared by KPMG ...
World Agroforestry Centre
core   +1 more source

Evaluation of nationwide variation in post-haemorrhagic ventricular dilatation management following national guideline implementation in the Netherlands. [PDF]

Childs Nerv Syst
Bertens JPF, Woerdeman PA, de Vries LS, van den Bosch GE, Steggerda SJ, Spoor JKH, Smit LS, Buis DR, Koot RW, Aalbers MW, Jeltema HR, van Aalst J, van der Aa NE, Tataranno ML, Weeke LC, Ter Horst HJ, de Haan TR, Vermeulen RJ, Dijkman KP, Tollenaer SMM, Roze E, Rooda OHJE.   +21 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Correction: Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax. [PDF]

J Exp Clin Cancer Res
Gaur T, Poddutoori R, Khare L, Bagal B, Rashmi S, Patkar N, Tembhare P, Pg S, Shetty D, Dutt A, Zhang Q, Konopleva M, Platzbeckar U, Gupta S, Samajdar S, Ramchandra M, Khattry N, Hasan SK.   +17 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Terra valenciana : publicació del Centre Regionaliste: Any I Número 1 - 21 juny 1908

, 1908
Microfilme.
Centre Regionalista Valencià, Imprenta de Manuel Pau   +1 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus. [PDF]

Nature
Morawetz I, Riebner T, De Col LT, Schneider F, Sempelmann N, Schaden F, Bartokos M, Kazakov GA, Lahs S, Beeks K, Gerstenecker B, Grüneis A, Pimon M, Schumm T, Lal V, Zitzer G, Petrov V, Tiedau J, Okhapkin MV, Peik E.   +19 more
europepmc   +1 more source