Results 91 to 100 of about 1,822,710 (231)

Numerical Flow Analysis in a Rotating Square Duct and a Rotating Curved-Duct

open access: yesInternational Journal of Rotating Machinery, 2000
A numerical study is conducted on the fully-developed laminar flow of an incompressible viscous fluid in a square duct rotating about a perpendicular axis to the axial direction of the duct. At the straight duct, the rotation produces vortices due to the
Je Hyun Baekt, Chang Hwan Ko
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

open access: yesAdvanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang   +14 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

open access: yesAdvanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng   +19 more
wiley   +1 more source

Computer precision simulation for titanium casting centrifugal mold filling of prescision titanium castings [PDF]

open access: yesChina Foundry, 2004
Computer simulation codes were developed based on proposed mathematical model for centrifugal mold filling processes and previous computer software for 3D mold filling and solidification of castings.
Daming XU, Xin LI, Geving AN
doaj  

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

open access: yesAdvanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu   +7 more
wiley   +1 more source

Deskilled and Rapid Drug-Resistant Gene Detection by Centrifugal Force-Assisted Thermal Convection PCR Device. [PDF]

open access: yesSensors (Basel), 2021
Espulgar WV   +8 more
europepmc   +1 more source

Hydraulic force and impellor evaluation of a centrifugal heart pump

open access: yes, 2004
A rig was constructed to test the performance characteristics and compare the hydraulic forces exerted on a centrifugal type artificial heart impeller. A conventional shaft, seal and bearing system, while driven by a small electric motor, supported the ...
Pearcy, Mark   +7 more
core  

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