Results 51 to 60 of about 744,926 (184)

Isolation of N-Ethyl-2-pyrrolidinone-Substituted Flavanols from White Tea Using Centrifugal Countercurrent Chromatography Off-Line ESI-MS Profiling and Semi-Preparative Liquid Chromatography

Molecules, 2021
N-Ethyl-2-pyrrolidinone-substituted flavanols (EPSF) are marker compounds for long-term stored white teas. However, due to their low contents and diasteromeric configuration, EPSF compounds are challenging to isolate.
Weidong Dai, Maria Ramos-Jerz, Dongchao Xie, Jiakun Peng, Peter Winterhalter, Gerold Jerz, Zhi Lin   +6 more
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Separation of Aeruginosin-865 from Cultivated Soil Cyanobacterium ( sp.) by Centrifugal Partition Chromatography combined with Gel Permeation Chromatography

Natural Product Communications, 2015
Aeruginosin-865 was isolated from cultivated soil cyanobacteria using a combination of centrifugal partition chromatography (CPC) and gel permeation chromatography.
José Cheel, Mirjana Minceva, Petra Urajová, Rabya Aslam, Pavel Hrouzek, Jiři Kopecký   +5 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Prediction of Bleeding via Simulation of Hydrodynamics in Centrifugal Partition Chromatography

Separations
Centrifugal Partition Chromatography (CPC) utilizes a two-phase liquid–liquid system as mobile and stationary phases. During operation, the latter continuously drains out of the rotor, despite it being in fact stationary, leading to decreasing separation
Felix Buthmann, Sophia Volpert, Jörg Koop, Gerhard Schembecker   +3 more
doaj   +1 more source

Joule self‐heating enabled oxygen transport and coupled methane reactions in a La0.6Sr0.4Co0.2Fe0.8O3‐δ hollow fiber membrane reactor

AIChE Journal, EarlyView.
Abstract Mixed‐conducting ceramic hollow fiber membranes are a versatile platform for oxygen separation, value‐added chemical production, and oxy‐combustion. Because oxygen permeation is thermally activated, these systems typically rely on bulky, energy‐intensive furnaces that suffer from low efficiency and large thermal inertia.
Gang Wang, Hamed Abdolahimansoorkhani, Xingjian Xue   +2 more
wiley   +1 more source

Counteracting Bleeding in Centrifugal Partition Chromatography: Redosing of the Stationary Phase

Separations
Centrifugal Partition Chromatography is a type of Liquid-Liquid Chromatography that offers several advantages compared to Liquid Chromatography. Two immiscible liquids are utilized, and one phase has to be immobilized to implement chromatographic ...
Felix Buthmann, Jan Hohlmann, Sophia Volpert, Mareen Neuwald, Djamal Hamza, Gerhard Schembecker   +5 more
doaj   +1 more source

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source

Preparative Separation of Acylglycerol by Centrifugal Partition Chromatography (CPC)

Journal of Japan Oil Chemists' Society, 1992
Reacted mixtures obtained by the esterification of three purified fatty acids (oleic acid, icosapentaenoic acid, and docosahexaenoic acid) with glycerol were separated and purified into triacylglycerol, diacylglycerol, monoacylglycerol, and free fatty acid fractions by centrifugal partition chromatography (CPC).Two solvents were used in combination for
TANAKA, Yukihisa, FUNADA, Tadashi, MURAYAMA, Wataru, KOSUGE, Yasutaka   +3 more
openaire   +3 more sources

Strategic construction of fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents for amplifying cancer phototheranostics

FlexMat, EarlyView.
The development of conventional phototheranostic nanomedicines suffers from an intrinsic trade‐off between NIR‐II fluorescence emission and phototherapeutic effects, leading to poor overall efficacy. Herein, we propose an innovative fluorination strategy by constructing fluorinated surroundings in NIR‐II‐emissive organic semiconducting agents to ...
Xiaoming Hu, Achen Qin, Caijun Zhu, Jinshuo Mi, Zejing Chen, Jiaying Shao, Zhen Li, Zhen Yang   +7 more
wiley   +1 more source