Results 121 to 130 of about 1,302,968 (344)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Journal of Head & Neck Physicians and Surgeons, 2015 Platelet-rich fibrin (PRF) or leucocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets and leucocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue.
Aruna Tambuwala +3 more
doaj
Use of magnetic filtration in waste water treatment [PDF]
Acta Montanistica Slovaca, 2012 The materials based on iron oxides are widely used for toxic elements removal. Magnetite nanoparticles are good sorbentof arsenic from water, but their practical use is quite limited.
Katarína Štefušová +3 more
doaj
Comparison between partial concentration extraction and differential centrifugation.
, 2014 Comparison between partial concentration extraction and differential centrifugation.
Wanjun Hao (633811) +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Centrifugation of whole blood increases signal in hand-held luminometer.
The spLUC assay was run as previously described and the RLU signal was compared with and without centrifugation of the red cells. Centrifugation increased the signal by 5-fold for this sample from a vaccinated volunteer. (TIF)
Axel Jacobsen (18004487) +12 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Purification of viruses by centrifugation
, 2015 Ultracentrifugation provides a means to concentrate, analyze, and purify viruses in solution, and therefore represents an invaluable tool for aquatic virologists. This chapter reviews the theory of ultracentrifugation and presents the technical knowledge
J. Lawrence, G. Steward
semanticscholar +1 more source