Results 101 to 110 of about 1,676,115 (338)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Effects of centrifugation on gonadal and adrenocortical steroids in rats [PDF]
Many endocrine systems are sensitive to external changes in the environment. Both the pituitary adrenal and pituitary gonadal systems are affected by stress including centrifugation stress.
Butte, J. C., Kakihana, R.
core +1 more source
, 2009 We investigate the competition between spinodal decomposition and dynamical arrest using aqueous solutions of the globular protein lysozyme as a model system for colloids with short-range attractions.
Anna Stradner +4 more
core +1 more source
Cryopreservation of ovine in vitro produced embryos using centrifugation and cytocalasin D [PDF]
, 2013 The cryosurvival of ovine in vitro produced embryos are still low, thus preventing its routine transfer. Attempts have been made to override this problem by decreasing embryos lipid content or protecting their structure with cytoskeletal stabilizers.
Barbas, João +7 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Effects of Different Centrifugation Parameters on Equilibrium Solubility Measurements
Methods and ProtocolsThe bioavailability of a drug is closely linked to its solubility, making its early determination essential in drug development. The saturation shake-flask (SSF) method is the gold standard protocol for this, which includes a phase separation step—either
Rita Szolláth +4 more
doaj +1 more source
Relevant Aspects of Centrifugation Step in the Preparation of Platelet-Rich Plasma
ISRN Hematology, 2014 Introduction. Platelet-Rich Plasma (PRP) is rich in growth factors, playing important role in tissue healing. The wide variation of reported protocols for preparation of PRP leads to variable compositions, which induce different biological responses and ...
A. G. Perez +5 more
semanticscholar +1 more source
Effect of Sustained Human Centrifugation on Autonomic Cardiovascular and Vestibular Function [PDF]
, 2002 Repeated exposure to +Gz enhances human baroreflex responsiveness and improves tolerance to cardiovascular stress. However, both sustained exposure to +Gx and changes in otolith function resulting from the gravitational changes of space flight and ...
Benavides, Edgar W. +5 more
core +1 more source
抗原および抗ヒトIgEに対する好塩基球の反応性. 1.好塩基球数の変化 [PDF]
, 1992 Blood basophils in subjects with bronchial asthma migrate from blood stream into local allergic reaction sites after inhalation of antigen into airways. The phenomena can be observed by changes in number of basophils in the peripheral blood.
Kimura, Ikuro, Tanizaki, Yoshiro
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source