Results 161 to 170 of about 1,086,991 (312)

Effects of centrifugation on gonadal and adrenocortical steroids in rats

, 1980
Many endocrine systems are sensitive to external changes in the environment. Both the pituitary adrenal and pituitary gonadal systems are affected by stress including centrifugation stress.
Butte, J. C., Kakihana, R.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Influence of harvesting method on biomass yield and antimicrobial activity of Isochrysis galbana and Phaeodactylum tricornutum extracts. [PDF]

Biotechnol Lett
Freitas de Siqueira Junior E, Fernandez LG, Rodrigues ED, da Cunha Lima ST.   +3 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Mass Cytometry Reveals Comparable Proportions of Leukocyte Subsets and Cell Surface P2X7 or CD39 on Human Peripheral Blood Mononuclear Cell Samples Isolated by Ficoll-Paque or SepMate Tube Density Gradient Centrifugation. [PDF]

Cells
Elhage A, Gunasegaran B, Smith N, Turner RJ, Watson D, McGuire HM, Sluyter R.   +6 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Recent Advances in Bacterial Separation and Enrichment from Blood for the Diagnosis of Bloodstream Infections. [PDF]

Sensors (Basel)
Wang HB, Zhang ZZ, Liu Q, Lu HB, Jiang JH, Yu RQ, Tang H.   +6 more
europepmc   +1 more source

Modélisation statistique d'un procédé de centrifugation

, 2019
International audienceThis article describes a statistical analysis applied on a centrifugation process of Saint-Gobain. The correlations within data were analysed by PCA, and some statistical models were built using information from the previous step ...
Chambrion, Thomas, Liu, Zhanhao, Perrodin, Marion, Stoica, Radu   +3 more
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Streamlined molecular farming of plant virus therapeutics for space flight and other low-resource environments. [PDF]

NPJ Sci Plants
Opdensteinen P, Lewin K, Jain A, Copeland A, Copeland J, Ghazinejad M, Steinmetz NF.   +6 more
europepmc   +1 more source