Results 151 to 160 of about 23,096 (306)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Centrifuge Modeling Investigation of Geosynthetic-Reinforced and Pile-Supported Embankments

Geosynthetic-reinforced and pile-supported embankments (GRPSEs) encompass two core components of the aforementioned reinforced embankment and the underlying composite foundation.
Jiang, Y, He, N, Xu, B, Fan, W, Li, ST
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Recent Advances in Centrifuge Modeling of Seismic Shaking

, 1995
This State-of-the-Art paper focuses primarily on aspects of dynamic centrifuge modeling related to simulation of earthquake effects. New shaker mechanisms and model containers are described and soil- container-shaker interaction is discussed.
Kutter, Bruce L.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Potentialities and challenges of centrifuge modelling on unsaturated soils

, 2010
The behavior of geotechnical structures located near the soil surface is highly influenced by unsaturated soil conditions. Some researches about the potentialities of centrifuge modeling of geotechnical problems involving unsaturated soils are presented,
Caicedo, B., Thorel, Luc, Tristancho, J.
core  

Urgent samples in clinical laboratories: stochastic batching to minimize patient turnaround time. [PDF]

Health Care Manag Sci
Novak A, Gnatowski A, Sucha P.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hypergravity experiments on meter-scale porous media flow for geological carbon sequestration. [PDF]

Sci Rep
Lopez-Saavedra S, Bajestani MS, Pantov D, Chalaturnyk R, Zambrano-Narvaez G.   +4 more
europepmc   +1 more source

Modeling for control of centrifugal compressors

, 2013
Downsizing and turbocharging of engines provide a way to meet increasing demands for efficiency and performance in the automotive industry. An engine design is a result of compromises, e.g. the selection of charging system, and the trend is to reduce these compromises by increasing system complexity.
openaire   +1 more source