Results 101 to 110 of about 1,590,241 (290)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Assessment of bridge natural frequency as an indicator of scour using centrifuge modelling. [PDF]

J Civ Struct Health Monit, 2020
Kariyawasam KD, Middleton CR, Madabhushi G, Haigh SK, Talbot JP.   +4 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

HPMC viscous fluid for centrifuge modelling [PDF]

Dynamic pile installation is a challenging aspect of offshore infrastructure realisation. Due to the large scale and specialised hardware involved, researchers employ centrifuge modelling to study this process at a manageable scale in a controlled ...
Quinten, Tristan, Cabrera, Miguel, Askarinejad, Amin, Gavin, Kenneth   +3 more
core   +1 more source

Application of a Non-Coaxial Soil Model with an Anisotropic Yield Criterion in Tunnelling

Advances in Materials Science and Engineering, 2019
Soil strength isotropy and coaxiality of the principal axes of stress and plastic strain rate tensors are often assumed in modelling the soils around tunnels, in the conventional plastic theory.
Ran Yuan, Jia-Rong Zhang, Jian Cui, Wen-Ming Wang, Yi He, Yong Fang   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Centrifuge modelling of capillary rise

, 2001
This paper reports results from centrifuge tests designed to investigate capillary rise in soils subjected to different gravitational fields. The experimental programme is part of the EU-funded NECER project (Network of European Centrifuges for ...
Burkhart, S., Davies, MCR, Depountis, N, 2nd British-Geotechnical-Society Geoenvironmental Engineering Conference, Craig, W. H., Craig, WH, L. Thorel, M.C.R. Davies, Thorel, L., A. Rezzoug, Depountis, N., S. Burkhart, Davies, M. C R, Merrifield, C., Rezzoug, A, Rezzoug, A., Harris, C, Konig, D, Thorel, L, C. Merrifield, N. Depountis, C. Harris, D. König, König, D., W.H. Craig, Merrifield, C, Harris, C., Burkhart, S   +27 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source