Results 111 to 120 of about 48,590 (308)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Investigation and modelling of large scale cratering events : Lessons learnt from experimental analysis [PDF]
, 2011 Initiated as part of the 2010 Spin Your Thesis campaign, a new ESA Education programme, a group from the University of Glasgow Space Advanced Research Team successfully conducted a series of impact cratering experiments under a highly accelerated ...
Gibbings, Alison +2 more
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Modeling asteroid collisions and impact processes
, 2015 As a complement to experimental and theoretical approaches, numerical modeling has become an important component to study asteroid collisions and impact processes.
Holsapple, Keith +3 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Application of a Non-Coaxial Soil Model with an Anisotropic Yield Criterion in Tunnelling
Advances in Materials Science and Engineering, 2019 Soil strength isotropy and coaxiality of the principal axes of stress and plastic strain rate tensors are often assumed in modelling the soils around tunnels, in the conventional plastic theory.
Ran Yuan +5 more
doaj +1 more source
Impact cratering experiments into highly porous bodies [PDF]
, 2011 Asteroids represent both an opportunity and a risk. Their pristine environment captures the early collision evolution of the solar system; while their inherent ground impact potential could result in the mass extinction of life.
Gibbings, Alison, Vasile, Massimiliano
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Assessing the link between the Geochemistry of Soils and the Bioaccessibility of Arsenic, Chromium and Lead in the Urban Environment [PDF]
, 2012 One of the principal pathways for potentially harmful elements (PHE) in soil to enter the human body is through ingestion. The amount of PHE which enters the systemic circulation is governed by the amount of PHE released in the Gastrointestinal Tract ...
Cave, Mark, Wragg, Joanna
core