Results 51 to 60 of about 15,964,666 (310)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Centrifuge model test study on pile-anchor support system
Soils and FoundationsWith the increasing development of underground engineering, various support systems of foundation pits are emerging, and the pile-anchor support system is widely used in deep foundation pit engineering construction. A series of centrifuge model tests for
Xiaomeng Xue, Ga Zhang
doaj +1 more source
Yantu gongcheng xuebao, 2020 The miniature pore water pressure transducer is one of the key measurement tools in the geotechnical centrifuge model tests. Compared with the imported transducers, the domestic transducers still have a great distance in response accuracy, frequency ...
TANG Zhao-guang , WANG Yong-zhi , SUN Rui , DUAN Xue-feng , WANG Ti-qiang , WANG Hao-ran
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Journal of Marine Science and EngineeringThis study investigates the monotonic and cyclic performance of composite bucket foundation breakwater in clay through centrifuge modeling. The application of monotonic loads simulates extreme wave conditions, and cyclic load corresponds to long-term ...
Minmin Jiang +3 more
doaj +1 more source
, 2020 Some offshore wind farms are built in seismically active areas. The offshore wind turbine (OWTs) are high-rise structures and sensitive to lateral failures during the earthquake.
Xuefei Wang +3 more
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cyclic p-y Curves of Monopiles in Dense Dry Sand Using Centrifuge Model Tests
Applied Sciences, 2019 In this study, centrifuge model tests were used to examine the lateral behavior of a monopile embedded in dry sand through cyclic lateral loading tests.
Myungjae Lee +3 more
doaj +1 more source