Results 121 to 130 of about 62,229 (263)

Toddlers and terriers: a One Health partnership to combat antimicrobial resistance

Journal of Small Animal Practice, EarlyView.
M. Prodanuk, F. Emdin
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Tissue and Serum Concentrations of Time‐Dependent Antibiotics in Infected Diabetic Foot Ulcers by Bolus or Continuous Administration: The Randomised DFIATIM Trial

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The clinical effectiveness of antibiotic (ATB) therapy in patients with infected diabetic foot ulcers (iDFUs) depends on achieving sufficient ATB concentrations in both serum and peripheral tissues. This study evaluated the availability and bactericidal activity of the time‐dependent ATBs—ceftazidime (CTZ) and amoxicillin/clavulanate (AMC)
Radka Jarošíková, Dominika Sojáková, Simona Antalová, Petr Tůma, Jan Polák, Michal Dubský, Andrea Němcová, Veronika Wosková, Pavol Beca, Istvan Modos, Jan Mareš, Jakub Mrázek, Chahrazed Mekadim, Markéta Skružná, Vladimíra Fejfarová   +14 more
wiley   +1 more source

Some Factors Influencing the Number of Clostridioides difficile Spores Detected in Hospital Wastewater

Infection and Drug Resistance
Chun-Wei Chiu,1 Shiang-En Chen,2 Yu-Ting Lin,2 Ching-Chi Lee,3– 5 Jen-Chieh Lee,4,5 Chin-Shiang Tsai,4– 6 Wen-Chien Ko,4,5 Chih-Hsuan Tsai,2,5,* Yuan-Pin Hung1,2,4,5,* 1Department of Internal Medicine, Tainan Hospital, Ministry of Health ...
Chiu CW, Chen SE, Lin YT, Lee CC, Lee JC, Tsai CS, Ko WC, Tsai CH, Hung YP   +8 more
doaj  

Fluoroquinolone prescribing to older adults following FDA boxed warnings: a comparative analysis. [PDF]

Antimicrob Steward Healthc Epidemiol
Jia M, Flory J, McGinty EE, Rosen T, Zhang Y.   +4 more
europepmc   +1 more source

Fluorinative Olefin Bond Functionalization of Selected Functionalized Cycloalkenes

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Palladium‐catalyzed ring olefin bond difunctionalization, through functional group and substrate‐dependent arylfluorination, of selected functionalized cycloalkenes has been studied. Palladium‐catalyzed ring olefin bond difunctionalization through arylfluorination of selected five‐, six‐, and seven‐membered functionalized cycloalkenes has been studied.
Tamás T. Novák, Tamás Holczbauer, Máté Sulyok‐Eiler, Pál T. Szabó, Melinda Nonn, Gábor Turczel, Anas Semghouli, Santos Fustero, Jianlin Han, Gábor Hornyánszky, Loránd Kiss   +10 more
wiley   +1 more source

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 7, July 2026.
ABSTRACT Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies for SSTIs. Additionally, we conduct population PK target attainment simulations for varying doses of cephalexin and cefadroxil for Staphylococcus ...
Jonathan H. Ryder, Shawnalyn W. Sunagawa, Nathaniel J. Rhodes, Trevor C. Van Schooneveld, Jeremy E. Tigh, Sean N. Avedissian, Nicolas Cortes‐Penfield   +6 more
wiley   +1 more source

Effect of alkaline pretreatment on cephalosporin degradation and microbial susceptibility in wastewater of cephalosporin drug manufacturing plant. [PDF]

Sci Rep
Ullah M, Rana MS, Hossain MM, Islam MK, Amin MS.   +4 more
europepmc   +1 more source

In utero ventriculosubgaleal shunt placement in a fetal lamb model: Phase 1 technical insights

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Background Progressive ventriculomegaly and the resulting irreversible brain damage may be mitigated through timely diversion prenatal intervention. While ventriculosubgaleal shunt (VSGS) is commonly performed postnatally in premature infants, in utero placement is unexplored.
Shohra Qaderi, Weston T. Northam, Soner Duru, Eyal Krispin, Nikan Zargarzadeh, Ali Javinani, Jose L. Peiro, Hamidreza Forourtan, Braxton Forde, Syril James, Scott A. Shainker, Arthur Nedder, Brittany Pattison, Lana Vasung, Lucas Peiro, Ryne A. Didier, Michaela K. Farber, Sebastian Seifert, Darren B. Orbach, P. Ellen Grant, Ramen H. Chmait, Benjamin C. Warf, Kjersti Aagaard, Yves Ville, Alireza A. Shamshirsaz   +24 more
wiley   +1 more source