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Pediatrics In Review, 1994
Introduction The first cephalosporin released for clinical use was cephalothin in 1964. Since that time, more than 20 cephalosporin antibiotics have been introduced. These are the most commonly prescribed antibiotics in the United States and account for the largest share of hospital expenditures. To determine which agent to use for an
T, Darville, T, Yamauchi
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Introduction The first cephalosporin released for clinical use was cephalothin in 1964. Since that time, more than 20 cephalosporin antibiotics have been introduced. These are the most commonly prescribed antibiotics in the United States and account for the largest share of hospital expenditures. To determine which agent to use for an
T, Darville, T, Yamauchi
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Journal of Medicinal Chemistry, 1977
The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6).
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The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6).
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Continuous deacetylation of cephalosporins
Biotechnology and Bioengineering, 1980AbstractContinuous deacetylation of cephalosporin C, 7âaminocephalosporanic acid, and of 2âmethoxyethyl acetate in packed beds of an immobilized esterase is described by simple empirical equations relating conversion to space velocity and temperature.
Jan, Konecny, M, Sieber
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Classification of Cephalosporins
Drugs, 1987Many cephalosporins are now in clinical use. They have a wide range of activity against different species of bacteria and also differ in their pharmacokinetic and metabolic characteristics. This article outlines a basis for comparison and classification of cephalosporins into 4 groups active mainly against: (1) Gram-positive bacteria; (2) Gram-negative
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Expert Opinion on Emerging Drugs, 2007
Several cephalosporins are in clinical development as broad-spectrum agents with potent activity against multi-resistant staphylococci as well as the Gram-positive and Gram-negative bacteria normally susceptible to advanced generation cephalsoporins. These agents represent a novel activity for the class and challenge a dogma that beta-lactams do not ...
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Several cephalosporins are in clinical development as broad-spectrum agents with potent activity against multi-resistant staphylococci as well as the Gram-positive and Gram-negative bacteria normally susceptible to advanced generation cephalsoporins. These agents represent a novel activity for the class and challenge a dogma that beta-lactams do not ...
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The immunosuppressive effect of cephalosporins and cephalosporin-gentamicin combinations
Journal of Antimicrobial Chemotherapy, 1981Human peripheral blood lymphocytes were cultured in several concentrations of each of 13 cephalosporins alone or in combination with gentamicin. Response to phytohaemagglutinin (PHA) was compared with that of cultures containing no antibiotics. No apparent immunoinhibitory effect could be detected for most cephalosporins.
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