Results 331 to 340 of about 165,861 (406)
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Journal of Medicinal Chemistry, 1977
The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6).
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The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6).
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Otolaryngology–Head and Neck Surgery, 1982
CHAIRMAN'S COMMENTS: During the past 15 years, a large number of cephalosporin antibiotics have been introduced for use in clinical practice. These cephalosporin agents present a confusing picture to the medical practitioner. In an attempt to simplify the indications for cephalosporin use in medical practice, Dr Rybak summarizes in this review the ...
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CHAIRMAN'S COMMENTS: During the past 15 years, a large number of cephalosporin antibiotics have been introduced for use in clinical practice. These cephalosporin agents present a confusing picture to the medical practitioner. In an attempt to simplify the indications for cephalosporin use in medical practice, Dr Rybak summarizes in this review the ...
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Expert Opinion on Emerging Drugs, 2007
Several cephalosporins are in clinical development as broad-spectrum agents with potent activity against multi-resistant staphylococci as well as the Gram-positive and Gram-negative bacteria normally susceptible to advanced generation cephalsoporins. These agents represent a novel activity for the class and challenge a dogma that beta-lactams do not ...
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Several cephalosporins are in clinical development as broad-spectrum agents with potent activity against multi-resistant staphylococci as well as the Gram-positive and Gram-negative bacteria normally susceptible to advanced generation cephalsoporins. These agents represent a novel activity for the class and challenge a dogma that beta-lactams do not ...
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EcoSal Plus
ABSTRACT Siderophore cephalosporins are designed to exploit bacterial nutrient uptake systems to gain accelerated uptake across the outer membrane of Gram-negative bacteria. They contain iron (III) binding motifs that allow them to form complexes that will be recognized as potential substrates by iron-siderophore ...
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ABSTRACT Siderophore cephalosporins are designed to exploit bacterial nutrient uptake systems to gain accelerated uptake across the outer membrane of Gram-negative bacteria. They contain iron (III) binding motifs that allow them to form complexes that will be recognized as potential substrates by iron-siderophore ...
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1998
Abstract The discovery of penicillin by Alexander Fleming in 1929 and the eventual clinical use of the purified product in the 1940s led to the search for other antibacterial agents produced by naturally occurring fungi. Giuseppi Brotzu was the first to isolate a cephalosporin from Cephalosporium acremonium in 1945.
James B Malow, John N Sheagren
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Abstract The discovery of penicillin by Alexander Fleming in 1929 and the eventual clinical use of the purified product in the 1940s led to the search for other antibacterial agents produced by naturally occurring fungi. Giuseppi Brotzu was the first to isolate a cephalosporin from Cephalosporium acremonium in 1945.
James B Malow, John N Sheagren
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Electrochemical determination of cephalosporins using a bare boron-doped diamond electrode.
Analytica Chimica Acta, 2017Bogdan Feier +3 more
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